Palladium-catalyzed oxidative cross-coupling of azole-4-carboxylates with indoles: an approach to the synthesis of pimprinine

被引：19

作者：

Zhou, Haipin ^{[1
,2
]}

Gai, Kuo ^{[1
,2
]}

Lin, Aijun ^{[1
,2
]}

Xu, Jinyi ^{[1
,2
]}

Wu, Xiaoming ^{[1
,2
]}

Yao, Hequan ^{[1
,2
]}

机构：

[1] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Jiangsu, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 04期

基金：

中国国家自然科学基金;

关键词：

H BOND ACTIVATION; SEQUENTIAL ARYLATION; HETEROARENES; ALKALOIDS; AZOLES; FUNCTIONALIZATION; HETEROARYLATION; PYRIDINES; ANILIDES; PYRROLES;

D O I：

10.1039/c4ob01844c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and straightforward method for the production of 5-(3-indolyl)azoles incorporating the privileged structures indoles and azoles via palladium-catalyzed double C-H bond cleavage under mild conditions was disclosed. As expected, this protocol provided an easy method for the synthesis of indole alkaloids pimprinine and WS-30581 A in moderate yields.

引用

页码：1243 / 1248

页数：6

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