Pulmonary Surfactant Pathophysiology: Current Models and Open Questions

被引：217

作者：

Perez-Gil, Jesus ^{[1
,2
]}

Weaver, Timothy E. ^{[3
]}

机构：

[1] Univ Complutense, Dept Bioquim, Fac Biol, E-28040 Madrid, Spain

[2] Cincinnati Childrens Res Fdn, Cincinnati, OH USA

[3] Univ Cincinnati, Coll Med, Cincinnati, OH USA

来源：

PHYSIOLOGY | 2010年 / 25卷 / 03期

关键词：

PROTEINS SP-B; PHOSPHOLIPID-TRANSFER PROTEINS; PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE-ALPHA; CAUSES RESPIRATORY-FAILURE; EARLY EMBRYONIC LETHALITY; LUNG SURFACTANT; SP-C; LAMELLAR BODY; II CELLS; MEMBRANE-PROTEIN;

D O I：

10.1152/physiol.00006.2010

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Pulmonary surfactant is an essential lipid-protein complex that stabilizes the respiratory units (alveoli) involved in gas exchange. Quantitative or qualitative derangements in surfactant are associated with severe respiratory pathologies. The integrated regulation of surfactant synthesis, secretion, and metabolism is critical for air breathing and, ultimately, survival. The goal of this review is to summarize our current understanding and highlight important knowledge gaps in surfactant homeostatic mechanisms.

引用

页码：132 / 141

页数：10

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