Isolation and bioactivities of epidioxysterol from the tunicate Cynthia savignyi

被引：10

作者：

Abourriche, A

Charrouf, M

Chaib, N

Bennamara, A

Bontemps, N

Francisco, C

机构：

[1] Fac Sci Ben Msik, Associe CNR, Lab Chim Organ Biomol, Casablanca, Morocco

[2] Ctr Phytopharm, URA 612, Grp Biomol, F-66860 Perpignan, France

来源：

FARMACO | 2000年 / 55卷 / 6-7期

关键词：

Cynthia savignyi; epidioxysterol; antibacterial; antifungal; cytotoxicity;

D O I：

10.1016/S0014-827X(00)00040-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

From a hexane extract of the tunicate Cynthia savignyi, collected in Morocco, epidioxysterol or 5,8-alpha -epidioxy-5 alpha -cholest-6-en-3 beta -ol has been isolated. This is the first example of epidioxysterol found in the tunicate C. savignyi. The structure of epidioxysterol has been characterised by NMR data (H-1, C-13 and 2D). Epidioxysterol possesses antifungal activity against three tomato pathogenic fungi: Botrytis cinerea, Fusarium oxysporum and Verticillium albo atrum and antibacterial activity against Agrobacterium tumefaciens, Escherichia coli, Staphylococcus faecalis, Staphylococcus aureus and Pseudomonas aeruginosa and cytotoxicity against Artemia salina larvae. (C) 2000 Published by Elsevier Science S.A. All rights reserved.

引用

页码：492 / 494

页数：3

共 7 条

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[2]

FAULKNER DJ, 1990, NAT PROD REP, V7, P97

[3]

LINTANDON M, 1991, TETRAHEDRON LETT, V32, P911

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