SEARCH FOR NEW DRUGS SYNTHESIS AND ANTITUMOR ACTIVITY OF 3,4,5-SUBSTITUTED 1,2,4-TRIAZOLES

被引：6

作者：

Ovsepyan, T. R. ^{[1
]}

Melik-Ogandzhanyan, R. G. ^{[1
]}

Panosyan, G. A. ^{[1
]}

Arsenyan, F. G. ^{[1
]}

Garibdzhanyan, B. T.

机构：

[1] Natl Acad Sci Armenia, Mndzhoyan Inst Fine Organ Chem, Mol Struct Res Ctr, Yerevan, Armenia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2009年 / 43卷 / 12期

关键词：

synthesis; 1,2,4-triazole; antitumor activity;

D O I：

10.1007/s11094-010-0371-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Conditions for effective alkylation of new 3,4-substituted-5-mercapto-1,2,4-triazoles with various alkylating agents are established. Several compounds possessing pronounced antitumor activity have been found in experiments using two xenograft tumor models.

引用

页码：645 / 648

页数：4