Simultaneous determination of Mometasone Furoate and salicylic acid in complex matrix using green analytical method

A green capillary zone electrophoretic method (CZE) has been developed and validated for the analysis of mometasone furoate (MF) and salicylic acid (SAL) simultaneously in synthetic mixtures and topical preparation (Elicasal (R) ointment) in a ratio of 1: 50 (MF: SAL). The proposed CZE method showed linear response for both MF and SAL in concentration ranges 0.2 - 40 mu g/mL and 0.1 - 80 mu g/mL, respectively. The detection and quantification limits for the assay of MF were 0.04 and 0.13 mu g/mL, and of SAL were 0.03 mu g/mL and 0.1 mu g/mL, respectively. The suggested procedure is successfully used for the accurate and precise determination of the binary mixture in bulk powder and in Elicasal (R) ointment. The main advantages of the proposed method are being sensitive, selective, inexpensive and rapid with the use of fewer quantities of solvents and analytical reagents. The proposed method was validated according to ICH guidelines. Comparison between the proposed method and reported ones, using Green Analytical Procedure Index (GAPI) and the Eco-scale penalty points approach (PPs), shows that the developed method is a better eco-friendly method than the reported ones.