All-trans retinoic acid (atRA) release from atRA-Loaded Folate-Poly(ethylene glycol)/Polyethylenimine nanoparticles for folate-mediated tumor targeting

被引：0
|
作者：
Yoo, Mi-Kyong [1 ]
Kim, You-Kyoung [1 ]
Jeong, Hwan-Jeong [2 ]
Bom, Hee-Seung [3 ]
Cho, Chong-Su [1 ]
机构：
[1] Seoul Natl Univ, Sch Agr Biotechnol, Seoul 151, South Korea
[2] Chonbuk Natl Univ, Sch Med, Dept Nucl Med, Jenju 561712, South Korea
[3] Chonnam Natl Univ, Sch Med, Dept Nucl Med, Gwangju 501746, South Korea
来源：
ASBM7: ADVANCED BIOMATERIALS VII | 2007年 / 342-343卷
关键词：
all-trans retionic acid; poly(ethylene glycol)-g-poly(ethylenimine) copolymer; Micelle; drug-polymer complex; folate; turmor-targeting;
D O I：
10.4028/www.scientific.net/KEM.342-343.509
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
To improve the specific accumulation in tumor sites and aqueous solubility of atRA, the core-shell type of folate-PEG-g-PEI/atRA nanoparticles were prepared by complexation between cationic PEI segments in the copolymers and anionic charged atRA, and tl en characterized by H-1-NMR, ELS, XRD, and TEM. In vitro atRA release from the nanoparticles was investigated as a function of drug content in sink condition. Cylotocicity of atRA against HepG2, KB cell lines were also evaluated by MTT assay. The lower the drug content, the faster atRA release. atRA incorporated in folate-PEG-g-PEI/atRA nanoparticles showed much higher cytotoxic effect compared with atRA itself.
引用
收藏
页码：509 / +
页数：2
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