Characterization of immune responses in fully vaccinated individuals after breakthrough infection with the SARS-CoV-2 delta variant

被引：52

作者：

Collier, Ai-Ris Y. ^{[1
,2
,3
]}

Brown, Catherine M. ^{[4
]}

McMahan, Katherine A. ^{[1
]}

Yu, Jingyou ^{[1
]}

Liu, Jinyan ^{[1
]}

Jacob-Dolan, Catherine ^{[1
,2
]}

Chandrashekar, Abishek ^{[1
]}

Tierney, Dylan ^{[4
]}

Ansel, Jessica L. ^{[1
]}

Rowe, Marjorie ^{[1
]}

Sellers, Daniel ^{[1
]}

Ahmad, Kunza ^{[1
]}

Aguayo, Ricardo ^{[1
,3
]}

Anioke, Tochi ^{[1
]}

Gardner, Sarah ^{[1
]}

Siamatu, Mazuba ^{[1
]}

Bermudez-Rivera, Lorraine ^{[1
]}

Hacker, Michele R. ^{[2
,3
]}

Madoff, Lawrence C. ^{[4
]}

Barouch, Dan H. ^{[1
,2
,5
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02115 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

[3] Beth Israel Deaconess Med Ctr, Dept Obstet & Gynecol, Boston, MA 02215 USA

[4] Massachusetts Dept Publ Hlth, Boston, MA 02108 USA

[5] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2022年 / 14卷 / 641期

关键词：

D O I：

10.1126/scitranslmed.abn6150

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Breakthrough infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have been reported frequently in vaccinated individuals with waning immunity. In particular, a cluster of over 1000 infections with the SARS-CoV-2 delta variant was identified in a predominantly fully vaccinated population in Provincetown, Massachusetts in July 2021. In this study, vaccinated individuals who tested positive for SARS-CoV- 2 (n = 16) demonstrated substantially higher serum antibody responses than vaccinated individuals who tested negative for SARS-CoV-2 (n = 23), including 32-fold higher binding antibody titers and 31-fold higher neutralizing antibody titers against the SARS-CoV-2 delta variant. Vaccinated individuals who tested positive also showed higher mucosal antibody responses in nasal secretions and higher spike protein-specific CD8+ T cell responses in peripheral blood than did vaccinated individuals who tested negative. These data demonstrate that fully vaccinated individuals developed robust anamnestic antibody and T cell responses after infection with the SARS-CoV-2 delta variant. Moreover, these findings suggest that population immunity will likely increase over time by a combination of widespread vaccination and breakthrough infections.

引用

页数：7

共 14 条

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Cooper, David ;

Frenck, Robert W., Jr. ;

Hammitt, Laura L. ;

Tureci, Ozlem ;

Nell, Haylene ;

Schaefer, Axel ;

Unal, Serhat ;

Tresnan, Dina B. ;

Mather, Susan ;

Dormitzer, Philip R. ;

Sahin, Ugur ;

Jansen, Kathrin U. ;

Gruber, William C. .

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Fennema, Hein ;

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Scheper, Gert ;

Taylor, Kimberly L. ;

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Treanor, John ;

Barouch, Dan H. ;

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Ryser, Martin F. ;

Marovich, Mary A. ;

Neuzil, Kathleen M. ;

Corey, Lawrence ;

Cauwenberghs, Nancy ;

Tanner, Tamzin ;

Hardt, Karin ;

Ruiz-Guinazu, Javier ;

Le Gars, Mathieu ;

Schuitemaker, Hanneke ;

Van Hoof, Johan ;

Struyf, Frank ;

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Talbot, Keipp ;

Casey, Jonathan D. ;

Mohr, Nicholas M. ;

Zepeski, Anne ;

McNeal, Tresa ;

Ghamande, Shekhar ;

Gibbs, Kevin W. ;

Files, D. Clark ;

Hager, David N. ;

Shchu, Arber ;

Prekker, Matthew E. ;

Erickson, Heidi L. ;

Gong, Michelle N. ;

Mohamed, Amira ;

Henning, Daniel J. ;

Steingrub, Jay S. ;

Peltan, Ithan D. ;

ten Lohuis, Caitlin C. ;

Duggal, Abhijit ;

Wilson, Jennifer G. ;

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Qadir, Nida ;

Chang, Steven Y. ;

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Kwon, Jennie H. ;

Exline, Matthew C. ;

Halasa, Natasha ;

Chappell, James D. ;

Lauring, Adam S. ;

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Stubblefield, William B. ;

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Mills, Lisa ;

Lester, Sandra N. ;

Stumpf, Megan M. .

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← 1 2 →

共 14 条

[1] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[2] Outbreak of SARS-CoV-2 Infections, Including COVID-19 Vaccine Breakthrough Infections, Associated with Large Public Gatherings - Barnstable County, Massachusetts, July 2021 [J].

Brown, Catherine M. ;

Vostok, Johanna ;

Johnson, Hillary ;

Burns, Meagan ;

Gharpure, Radhika ;

Sami, Samira ;

Sabo, Rebecca T. ;

Hall, Noemi ;

Foreman, Anne ;

Schubert, Petra L. ;

Gallagher, Glen R. ;

Fink, Timelia ;

Madoff, Lawrence C. ;

Gabriel, Stacey B. ;

MacInnis, Bronwyn ;

Park, Daniel J. ;

Siddle, Katherine J. ;

Harik, Vaira ;

Arvidson, Deirdre ;

Brock-Fisher, Taylor ;

Dunn, Molly ;

Kearns, Amanda ;

Laney, A. Scott .

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2021, 70 (31) :1059-1062

[3] Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates [J].

Corbett, Kizzmekia S. ;

Flynn, Barbara ;

Foulds, Kathryn E. ;

Francica, Joseph R. ;

Boyoglu-Barnum, Seyhan ;

Werner, Anne P. ;

Flach, Britta ;

O'Connell, Sarah ;

Bock, Kevin W. ;

Minai, Mahnaz ;

Nagata, Bianca M. ;

Andersen, Hanne ;

Martinez, David R. ;

Noe, Amy T. ;

Douek, Naomi ;

Donaldson, Mitzi M. ;

Nji, Nadesh N. ;

Alvarado, Gabriela S. ;

Edwards, Darin K. ;

Flebbe, Dillon R. ;

Lamb, Evan ;

Doria-Rose, Nicole A. ;

Lin, Bob C. ;

Louder, Mark K. ;

O'Dell, Sijy ;

Schmidt, Stephen D. ;

Phung, Emily ;

Chang, Lauren A. ;

Yap, Christina ;

Todd, John-Paul M. ;

Pessaint, Laurent ;

Van Ry, Alex ;

Browne, Shanai ;

Greenhouse, Jack ;

Putman-Taylor, Tammy ;

Strasbaugh, Amanda ;

Campbell, Tracey-Ann ;

Cook, Anthony ;

Dodson, Alan ;

Steingrebe, Katelyn ;

Shi, Wei ;

Zhang, Yi ;

Abiona, Olubukola M. ;

Wang, Lingshu ;

Pegu, Amarendra ;

Yang, Eun Sung ;

Leung, Kwanyee ;

Zhou, Tongqing ;

Teng, I-Ting ;

Widge, Alicia .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (16) :1544-1555

[4] SARS-CoV-2 Neutralization with BNT162b2 Vaccine Dose 3 [J].

Falsey, Ann R. ;

Frenck, Robert W., Jr. ;

Walsh, Edward E. ;

Kitchin, Nicholas ;

Absalon, Judith ;

Gurtman, Alejandra ;

Lockhart, Stephen ;

Bailey, Ruth ;

Swanson, Kena A. ;

Xu, Xia ;

Koury, Kenneth ;

Kalina, Warren ;

Cooper, David ;

Zou, Jing ;

Xie, Xuping ;

Xia, Hongjie ;

Tuereci, Ozlem ;

Lagkadinou, Eleni ;

Tompkins, Kristin R. ;

Shi, Pei-Yong ;

Jansen, Kathrin U. ;

Sahin, Ugur ;

Dormitzer, Philip R. ;

Gruber, William C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (17) :1627-1629

Fowlkes, Ashley ;

Gaglani, Manjusha ;

Groover, Kimberly ;

Thiese, Matthew S. ;

Tyner, Harmony ;

Ellingson, Katherine .

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2021, 70 (34) :1167-1169

[6] Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques [J].

Mercado, Noe B. ;

Zahn, Roland ;

Wegmann, Frank ;

Loos, Carolin ;

Chandrashekar, Abishek ;

Yu, Jingyou ;

Liu, Jinyan ;

Peter, Lauren ;

McMahan, Katherine ;

Tostanoski, Lisa H. ;

He, Xuan ;

Martinez, David R. ;

Rutten, Lucy ;

Bos, Rinke ;

van Manen, Danielle ;

Vellinga, Jort ;

Custers, Jerome ;

Langedijk, Johannes P. ;

Kwaks, Ted ;

Bakkers, Mark J. G. ;

Zuijdgeest, David ;

Rosendahl Huber, Sietske K. ;

Atyeo, Caroline ;

Fischinger, Stephanie ;

Burke, John S. ;

Feldman, Jared ;

Hauser, Blake M. ;

Caradonna, Timothy M. ;

Bondzie, Esther A. ;

Dagotto, Gabriel ;

Gebre, Makda S. ;

Hoffman, Emily ;

Jacob-Dolan, Catherine ;

Kirilova, Marinela ;

Li, Zhenfeng ;

Lin, Zijin ;

Mahrokhian, Shant H. ;

Maxfield, Lori F. ;

Nampanya, Felix ;

Nityanandam, Ramya ;

Nkolola, Joseph P. ;

Patel, Shivani ;

Ventura, John D. ;

Verrington, Kaylee ;

Wan, Huahua ;

Pessaint, Laurent ;

Van Ry, Alex ;

Blade, Kelvin ;

Strasbaugh, Amanda ;

Cabus, Mehtap .

NATURE, 2020, 586 (7830) :583-+

[7] Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants [J].

Pegu, Amarendra ;

O'Connell, Sarah ;

Schmidt, Stephen D. ;

O'Dell, Sijy ;

Talana, Chloe A. ;

Lai, Lilin ;

Albert, Jim ;

Anderson, Evan ;

Bennett, Hamilton ;

Corbett, Kizzmekia S. ;

Flach, Britta ;

Jackson, Lisa ;

Leav, Brett ;

Ledgerwood, Julie E. ;

Luke, Catherine J. ;

Makowski, Mat ;

Roberts, Paul C. ;

Roederer, Mario ;

Rebolledo, Paulina A. ;

Rostad, Christina A. ;

Rouphael, Nadine G. ;

Shi, Wei ;

Wang, Lingshu ;

Widge, Alicia T. ;

Yang, Eun Sung ;

Beigel, John H. ;

Graham, Barney S. ;

Mascola, John R. ;

Suthar, Mehul S. ;

McDermott, Adrian ;

Doria-Rose, Nicole A. .

SCIENCE, 2021, 373 (6561) :1372-+

[8] Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine [J].

Polack, Fernando P. ;

Thomas, Stephen J. ;

Kitchin, Nicholas ;

Absalon, Judith ;

Gurtman, Alejandra ;

Lockhart, Stephen ;

Perez, John L. ;

Perez Marc, Gonzalo ;

Moreira, Edson D. ;

Zerbini, Cristiano ;

Bailey, Ruth ;

Swanson, Kena A. ;

Roychoudhury, Satrajit ;

Koury, Kenneth ;

Li, Ping ;

Kalina, Warren V. ;

Cooper, David ;

Frenck, Robert W., Jr. ;

Hammitt, Laura L. ;

Tureci, Ozlem ;

Nell, Haylene ;

Schaefer, Axel ;

Unal, Serhat ;

Tresnan, Dina B. ;

Mather, Susan ;

Dormitzer, Philip R. ;

Sahin, Ugur ;

Jansen, Kathrin U. ;

Gruber, William C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (27) :2603-2615

[9] Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19 [J].

Sadoff, Jerald ;

Gray, Glenda ;

Vandebosch, An ;

Cardenas, Vicky ;

Shukarev, Georgi ;

Grinsztejn, Beatriz ;

Goepfert, Paul A. ;

Truyers, Carla ;

Fennema, Hein ;

Spiessens, Bart ;

Offergeld, Kim ;

Scheper, Gert ;

Taylor, Kimberly L. ;

Robb, Merlin L. ;

Treanor, John ;

Barouch, Dan H. ;

Stoddard, Jeffrey ;

Ryser, Martin F. ;

Marovich, Mary A. ;

Neuzil, Kathleen M. ;

Corey, Lawrence ;

Cauwenberghs, Nancy ;

Tanner, Tamzin ;

Hardt, Karin ;

Ruiz-Guinazu, Javier ;

Le Gars, Mathieu ;

Schuitemaker, Hanneke ;

Van Hoof, Johan ;

Struyf, Frank ;

Douoguih, Macaya .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (23) :2187-2201

Self, Wesley H. ;

Tenforde, Mark W. ;

Rhoads, Jillian P. ;

Gaglani, Manjusha ;

Ginde, Adit A. ;

Douin, David J. ;

Olson, Samantha M. ;

Talbot, Keipp ;

Casey, Jonathan D. ;

Mohr, Nicholas M. ;

Zepeski, Anne ;

McNeal, Tresa ;

Ghamande, Shekhar ;

Gibbs, Kevin W. ;

Files, D. Clark ;

Hager, David N. ;

Shchu, Arber ;

Prekker, Matthew E. ;

Erickson, Heidi L. ;

Gong, Michelle N. ;

Mohamed, Amira ;

Henning, Daniel J. ;

Steingrub, Jay S. ;

Peltan, Ithan D. ;

ten Lohuis, Caitlin C. ;

Duggal, Abhijit ;

Wilson, Jennifer G. ;

Gordon, Alexandra June ;

Qadir, Nida ;

Chang, Steven Y. ;

Mallow, Christopher ;

Rivas, Carolina ;

Babcock, Hilary M. ;

Kwon, Jennie H. ;

Exline, Matthew C. ;

Halasa, Natasha ;

Chappell, James D. ;

Lauring, Adam S. ;

Grijalva, Carlos G. ;

Rice, Todd W. ;

Jones, Ian D. ;

Stubblefield, William B. ;

Baughman, Adrienne ;

Womack, Kelsey N. ;

Lindsell, Christopher J. ;

Hart, Kimberly W. ;

Zhu, Yuwei ;

Mills, Lisa ;

Lester, Sandra N. ;

Stumpf, Megan M. .

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2021, 70 (38) :1337-1343

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