Nucleophilic aromatic substitution reactions under aqueous, mild conditions using polymeric additive HPMC

被引：21

作者：

Borlinghaus, Niginia ^{[1
]}

Ansari, Tharique N. ^{[2
]}

Braje, Leon H. ^{[1
]}

Ogulu, Deborah ^{[2
]}

Handa, Sachin ^{[2
]}

Wittmann, Valentin ^{[3
]}

Braje, Wilfried M. ^{[1
]}

机构：

[1] AbbVie Deutschland GmbH & Co KG, Neurosci Discovery Res, D-67061 Ludwigshafen, Germany

[2] Univ Louisville, Dept Chem, Louisville, KY 40292 USA

[3] Univ Konstanz, Dept Chem, D-78457 Constance, Germany

来源：

GREEN CHEMISTRY | 2021年 / 23卷 / 11期

关键词：

ORGANIC-SYNTHESIS; WATER; CHEMISTRY; CATALYSIS; NANOPARTICLES; ACCELERATION; SURFACTANTS; PERSPECTIVE; TPGS-750-M;

D O I：

10.1039/d1gc00128k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of the inexpensive, benign, and sustainable polymer, hydroxypropyl methylcellulose (HPMC), in water enables nucleophilic aromatic subsitution (SNAr) reactions between various nucleophiles and electrophiles. The mild reaction conditions facilitate a broad functional group tolerance that can be utilized for subsequent derivatization for the synthesis of pharmaceutically relevant building blocks. The use of only equimolar amounts of all reagents and water as reaction solvent reveals the greenness and sustainability of the methodology presented herein.

引用

页码：3955 / 3962

页数：8

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