Artificial recombination in forensic mtDNA population databases

被引：78
作者：
Bandelt, HJ
Salas, A
Lutz-Bonengel, S
机构：
[1] Univ Hamburg, Fachbereich Math, D-20146 Hamburg, Germany
[2] Fac Med, Inst Med Legal, Unidad Genet, Santiago De Compostela, Acoruna, Spain
[3] Univ Freiburg Klinikum, Inst Rechts Med, D-79104 Freiburg, Germany
来源：
INTERNATIONAL JOURNAL OF LEGAL MEDICINE | 2004年 / 118卷 / 05期
关键词：
mitochondrial DNA; error detection; recombination; networks;
D O I：
10.1007/s00414-004-0455-2
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
Artificial recombination of two or more mitochondrial DNA fragments from different samples would constitute a serious cause of error in forensic DNA typing, and yet one can demonstrate that such events have happened in the preparation of several published mtDNA databases. Focussed database searches, phylogenetic analysis, and network representations can highlight mosaic patterns and thus pinpoint sample mix-up. Therefore, we suggest that this approach should be applied to data prior to publication in order to uncover such errors in time.
引用
收藏
页码：267 / 273
页数：7
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