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No association between dopaminergic polymorphisms and response to treatment of binge-eating disorder
被引:4
|作者:
Heidinger, Brandon A.
[1
]
Cameron, Jameason D.
[1
]
Vaillancourt, Regis
[1
]
De Lisio, Michael
[2
,3
]
Ngu, Matthew
[2
]
Tasca, Giorgio A.
[4
]
Chyurlia, Livia
[4
]
Doucet, Eric
[2
]
Doucette, Steve
[5
]
Rivas, Ana Maria Obregon
[6
]
Goldfield, Gary S.
[1
]
机构:
[1] Childrens Hosp Eastern Ontario, Res Inst, Hlth Act Living & Obes Res Grp, Ottawa, ON, Canada
[2] Univ Ottawa, Sch Human Kinet, Fac Hlth Sci, Ottawa, ON, Canada
[3] Univ Ottawa, Dept Cellular & Mol Med, Ctr Neuromuscular Dis, Ottawa, ON, Canada
[4] Univ Ottawa, Sch Psychol, Ottawa, ON, Canada
[5] Dalhousie Univ, Dept Community Hlth & Epidemiol, Halifax, NS, Canada
[6] Univ San Sebastian, Escuela Nutr & Dietet, Fac Ciencias El Cuidado Salud, Concepcion, Chile
来源:
关键词:
Binge-eating;
Obesity;
MAO-A;
COMT;
Taq-1A;
DAT-1;
MENTAL-HEALTH;
GENE;
ATTACHMENT;
EPIDEMIOLOGY;
ADDICTION;
BEHAVIORS;
OBESITY;
RISK;
D O I:
10.1016/j.gene.2021.145538
中图分类号:
Q3 [遗传学];
学科分类号:
071007 ;
090102 ;
摘要:
Background: The genetics of binge-eating disorder (BED) is an emerging topic, with dopaminergic genes being implicated in its etiology due to the role that dopamine (DA) plays in food reward sensitivity and self-regulation of eating behavior. However, no study to date has examined if DA genes influence response to behavioral treatment of BED. Objective: The primary objective of this study was to examine the ability of DA-associated polymorphisms to predict BED treatment response measured using binge frequency over 12 months. As secondary objectives, this study examined cross-sectional relationships between these polymorphisms and anthropometrics in women living with and without BED and obesity. Methods: Women aged 18-64 years old were genotyped for the DA-related SNPs DRD2/ANKK1 Taq1A (rs1800497) and COMT (rs4680), as well as the DA-related uVNTRs DAT-1 (SLC6A3) and MAO-A. A multi-locus DA composite score was formed from these 4 polymorphisms using genotypes known to have a functional impact resulting in modified DA signaling. Binge frequency (Eating Disorder Examination - Interview) and body composition (Tanita BC-418) were assessed in a pre-post analysis to examine genetic predictors of treatment response in women living with obesity and BED. Secondary data analysis was conducted on a cross-sectional comparison of three groups of women enrolled in trial group treatment for BED: women living with obesity and BED (n = 72), obesity without BED (n = 27), and normal-weight without BED (n = 45). Results: There were no significant genotype x time interactions related to anthropometrics or binge frequency for any individual DA genotypes, or to the composite score reflecting DA availability. At baseline, there were no significant between-group differences in frequencies of DA-related alleles, nor were there associations between genotypes and anthropometrics. Conclusions: Our study found no evidence to suggest that the DRD2/ANKK1 Taq1A, COMT, MAO-A, or DAT-1 polymorphisms are associated with response to behavioral intervention for BED as measured by changes in binge frequency. Future studies should examine a greater variety of dopaminergic polymorphisms, other candidate genes that target other neurotransmitter systems, as well as examine their impact on both behavioral and pharmacological-based treatment for BED.
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