MiRNAs and Muscle Regeneration: Therapeutic Targets in Duchenne Muscular Dystrophy

被引：21
|
作者：
Aranega, Amelia Eva [1 ,2 ]
Lozano-Velasco, Estefania [1 ,2 ]
Rodriguez-Outeirino, Lara [1 ,2 ]
Ramirez de Acuna, Felicitas [1 ,2 ]
Franco, Diego [1 ,2 ]
Hernandez-Torres, Francisco [1 ,2 ,3 ]
机构：
[1] Univ Jaen, Fac Expt Sci, Dept Expt Biol, Paraje Lagunillas S-N, Jaen 23009, Spain
[2] Medina Fdn, Technol Pk Hlth Sci,Av Conocimiento 34, Granada 18016, Spain
[3] Univ Granada, Fac Med, Dept Biochem & Mol Biol & Immunol 3, Avda Invest 11, Granada 18016, Spain
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 08期
关键词：
microRNA; satellite cell; myogenesis; muscle regeneration; muscular dystrophies; REGULATES MYOBLAST PROLIFERATION; NECROSIS-FACTOR-ALPHA; LONG NONCODING RNA; SKELETAL-MUSCLE; SATELLITE CELLS; STEM-CELLS; MYOGENIC DIFFERENTIATION; GENE-EXPRESSION; DOWN-REGULATION; TRANSCRIPTION FACTOR;
D O I：
10.3390/ijms22084236
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
microRNAs (miRNAs) are small non-coding RNAs required for the post-transcriptional control of gene expression. MicroRNAs play a critical role in modulating muscle regeneration and stem cell behavior. Muscle regeneration is affected in muscular dystrophies, and a critical point for the development of effective strategies for treating muscle disorders is optimizing approaches to target muscle stem cells in order to increase the ability to regenerate lost tissue. Within this framework, miRNAs are emerging as implicated in muscle stem cell response in neuromuscular disorders and new methodologies to regulate the expression of key microRNAs are coming up. In this review, we summarize recent advances highlighting the potential of miRNAs to be used in conjunction with gene replacement therapies, in order to improve muscle regeneration in the context of Duchenne Muscular Dystrophy (DMD).
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页数：23
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