Enhancement of vitamin A skin absorption by cyclodextrins

被引：6
作者：
Weissel, S
Perly, B
Créminon, C
Ouvrard-Baraton, F
Djedaïni-Pilard, F
机构：
[1] Univ Picardie, Lab Glucides, F-80039 Amiens, France
[2] CEA Saclay, DSM, Drecam, Serv Chim Mol, F-91191 Gif Sur Yvette, France
[3] CEA Saclay, DSV, DRM, Serv Pharmacol & Immunol, F-91191 Gif Sur Yvette, France
[4] LVMH, Lab R&D Branche Parfums & Cosmet, F-45800 St Jean De Braye, France
来源：
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2004年 / 14卷 / 01期
关键词：
heptakis(2,6-di-O-methyl)cyclomaltoheptaose; vitamin A propionate; inclusion complex; skin absorption; immunoassay;
D O I：
10.1016/S1773-2247(04)50009-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Propionate of vitamin A (PVA) is a highly instable and poorly water-soluble molecule which is of real interest for therapeutics. 1: 1 gammaCD/PVA and 2:1 betaCD/PVA inclusion complexes are formed. A stability study using NMR and HPLC indicated that betaCD induced an accelerated degradation of PV4 but, conversely gammaCD could protect it efficiently for many months. A very stable and soluble complex can be formed between heptakis(2,6-di-O-methyl)cyclomaltoheptaose (Dimeb) and vitamin A propionate. This solution was used to form an aqueous get. The skin absorption of PVA and Dimeb through the stratum corneum, epidermis and the dermis of human skin were assayed by HPLC and by specific immunoassays, respectively. In presence of Dimeb, the amounts of PV4 inside the different skins were significantly higher. It was also demonstrated that Dimeb penetrated in every cutaneous layer and showed no significant difference between free and bound forms.
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收藏
页码：77 / 86
页数：10
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