Prognostic significance of adipocytokines and extracellular matrix activity in heart failure patients with high B-type natriuretic peptide

被引：20

作者：

Ho, Yi-Lwun ^{[1
,2
,3
]}

Lin, Yen-Hung ^{[1
,2
]}

Lee, Chi-Ming ^{[1
,2
]}

Hsu, Ron-Bin ^{[2
,4
]}

Ting, Hsiu-Tzu ^{[2
,5
]}

Chou, Nai-Kuan ^{[2
,4
]}

Chao, Chia-Lun ^{[1
,2
]}

Wang, Shoei-Shen ^{[2
,4
]}

Hsu, Hsiu-Ching ^{[1
,2
]}

Chen, Ming-Fong ^{[1
,2
]}

机构：

[1] Natl Taiwan Univ Hosp, Dept Internal Med, Div Cardiol, Taipei 100, Taiwan

[2] Natl Taiwan Univ, Coll Med, Taipei 10764, Taiwan

[3] Natl Taiwan Univ Hosp, Grad Inst Clin Med, Taipei 100, Taiwan

[4] Natl Taiwan Univ Hosp, Dept Surg, Taipei 100, Taiwan

[5] Natl Taiwan Univ Hosp, Dept Nursing, Taipei 100, Taiwan

来源：

CLINICAL BIOCHEMISTRY | 2009年 / 42卷 / 13-14期

关键词：

Adiponectin; Extracellular matrix; Heart failure; b-type natriuretic peptide; TOTAL CHOLESTEROL; ADIPONECTIN; MORTALITY; METALLOPROTEINASE-2; DYSFUNCTION; RISK; HYPERTENSION; HYPERTROPHY; ACTIVATION; MANAGEMENT;

D O I：

10.1016/j.clinbiochem.2009.06.013

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objectives: To perform risk stratification by serum adipocytokines and serum markers of extracellular matrix in heart failure patients with high b-type natriuretic peptide (BNP). Methods: Patients with heart failure were enrolled in this study. Serum adipocytokines and serum markers of extracellular matrix were analyzed. Results: In total, 131 patients were enrolled and followed-up for 240 +/- 174 days. Mortality was significantly associated with adiponectin, resistin, type III amioterminal propeptide of procollagen (PIIINP), matrix metalloproteinase-2 (MMP-2), tissue inhibitor of metalloproteinase 1 (TIMP-1), and serum creatinine. Heart failure-related admission was significantly associated with apelin, and PIIINP. Cox regression analysis identified that mortality and heart failure-related admissions were significantly associated with MMP-2 (P = 0.008) and PIIINP (P = 0.011), respectively. Conclusions: Serum markers of extracellular matrix rather than adipocytokines may warrant further risk stratification for impacting the prognosis of patients with heart failure with high BNP. (C) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：1407 / 1412

页数：6

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