Association of ADAM 33 Gene Polymorphisms with Keloid Scars in a Northeastern Chinese Population

被引：12

作者：

Han, Jianyu ^{[1
]}

Han, Jianfeng ^{[2
]}

Yu, Dongmei ^{[1
]}

Xiao, Jinling ^{[3
]}

Shang, Yong ^{[1
]}

Hao, Lijun ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 1, Plast & Cosmet Ctr, Harbin 150001, Peoples R China

[2] Harbin Med Univ, Affiliated Hosp 2, Dept Orthoped, Harbin 150001, Peoples R China

[3] Harbin Med Univ, Affiliated Hosp 2, Med Teaching & Res Sect, Harbin 150001, Peoples R China

来源：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2014年 / 34卷 / 03期

关键词：

Keloid scar; ADAM33; Single nucleotide polymorphism; Association study; EXPRESSION; PROTEINS; ASTHMA; RISK;

D O I：

10.1159/000366314

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Objective: To study the association between ADAM33 and keloid scars in the northeastern Chinese population. Methods: A total of 283 keloid scar patients and a control group of 290 healthy volunteers were recruited for this study. Six polymorphic loci (V4, T+1, T2, T1, S2 and Q-1) of ADAM33 were selected for genotyping. Genotypes were determined by using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. Results: We observed the frequency of the rs612709 A allele exhibited a significantly decreased frequency in cases than in controls(22 vs.39.6%, P<0.0001) We also found that the frequencies of H2 (GGAAGA) haplotypes was significantly higher in the case group than in the control group (P=0.041). In contrast, the haplotype H8 (GGGAGG) was more common in the control group than in the case group (P=0.022). Conclusions: Our data suggest that the ADAM33 polymorphisms may be associated with keloid scars in the northeastern Chinese population. Copyright (C) 2014 S. Karger AG, Basel

引用

页码：981 / 987

页数：7

共 25 条

[1] Keloid disease: clinical relevance of single versus multiple site scars [J].

Bayat, A ;

Arscott, G ;

Ollier, WER ;

Mc Grouther, DA ;

Ferguson, MWJ .

BRITISH JOURNAL OF PLASTIC SURGERY, 2005, 58 (01) :28-37

[2] Description of site-specific morphology of keloid phenotypes in an Afrocaribbean population [J].

Bayat, A ;

Arscott, G ;

Ollier, WER ;

Ferguson, MWJ ;

Mc Grouther, DA .

BRITISH JOURNAL OF PLASTIC SURGERY, 2004, 57 (02) :122-133

[3]

BLOOM D., 1956, NEW YORK STATE JOUR MED, V56, P511

[4] KELOIDS - A REVIEW OF THE LITERATURE [J].

DATUBOBROWN, DD .

BRITISH JOURNAL OF PLASTIC SURGERY, 1990, 43 (01) :70-77

[5]

EHRLICH HP, 1994, AM J PATHOL, V145, P105

[6] REGULATION OF COLLAGEN GENE-EXPRESSION IN KELOIDS AND HYPERTROPHIC SCARS [J].

FRIEDMAN, DW ;

BOYD, CD ;

MACKENZIE, JW ;

NORTON, P ;

OLSON, RM ;

DEAK, SB .

JOURNAL OF SURGICAL RESEARCH, 1993, 55 (02) :214-222

[7] Human ADAM33: protein maturation and localization [J].

Garlisi, CG ;

Zou, J ;

Devito, KE ;

Tian, F ;

Zhu, FX ;

Liu, JJ ;

Shah, H ;

Wan, YT ;

Billah, MM ;

Egan, RW ;

Umland, SP .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 301 (01) :35-43

[8] Keloid Scarring: Understanding the Genetic Basis, Advances, and Prospects [J].

Halim, Ahmad Sukari ;

Emami, Azadeh ;

Salahshourifar, Iman ;

Kannan, Thirumulu Ponnuraj .

ARCHIVES OF PLASTIC SURGERY-APS, 2012, 39 (03) :184-189

[9] ADAM33 expression in atherosclerotic lesions and relationship of ADAM33 gene variation with atherosclerosis [J].

Holloway, John W. ;

Laxton, Ross C. ;

Rose-Zerilli, Matthew J. ;

Holloway, Judith A. ;

Andrews, A. Lynn ;

Riaz, Zeshan ;

Wilson, Susan J. ;

Simpson, Iain A. ;

Ye, Shu .

ATHEROSCLEROSIS, 2010, 211 (01) :224-230

[10]

Marneros AG, 2001, ARCH DERMATOL, V137, P1429

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