Diastereoselective esterification of (±)-N-trifluoroacetyl pipecolic acid using (S)-α-methyl pantolactone:: synthesis of (S)-N-Boc pipecolic acid and (S)-N-Boc-2-piperidinemethanol

被引：11
作者：
Calmès, M
Escale, FO
Rolland, M
Martinez, J
机构：
[1] Univ Montpellier 1, CNRS, UMR 5810, Lab Aminoacides Peptides & Proteines, F-34095 Montpellier 5, France
[2] Univ Montpellier 2, F-34095 Montpellier 5, France
来源：
TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 12期
关键词：
D O I：
10.1016/S0957-4166(03)00304-5
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Racemic N-trifluoroacetyl pipecolic acid has been converted into (S)-N-Boc-pipecolic acid or (S)-N-Boc-2-piperidinemethanol by DCC/DMAP-induced diastereoselective esterification with (S)-alpha-methyl pantolactone, followed by a saponification or a reduction reaction and N-Boc protection. (C) 2003 Elsevier Science Ltd. All rights reserved.
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页码：1685 / 1689
页数：5
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