Microindolinone A, a Novel 4,5,6,7-Tetrahydroindole, from the Deep-Sea-Derived Actinomycete Microbacterium sp MCCC 1A11207

被引：25

作者：

Niu, Siwen ^{[1
]}

Zhou, Ting-Ting ^{[1
]}

Xie, Chun-Lan ^{[1
]}

Zhang, Gai-Yun ^{[2
]}

Yang, Xian-Wen ^{[1
,2
]}

机构：

[1] State Ocean Adm, Inst Oceanog 3, Key Lab Marine Genet Resources, State Key Lab Breeding Base Marine Genet Resource, 184 Daxue Rd, Xiamen 361005, Peoples R China

[2] State Ocean Adm, Inst Oceanog 3, Fujian Key Lab Marine Genet Resources, South China Sea Bioresource Exploitat & Utilizat, 184 Daxue Rd, Xiamen 361005, Peoples R China

来源：

MARINE DRUGS | 2017年 / 15卷 / 07期

基金：

中国国家自然科学基金;

关键词：

deep-sea; actinomycete; Microbacterium sp; indole; INDOLE ALKALOIDS; MARINE BACTERIUM; DISCOVERY; METABOLITES; STRAIN; FUNGUS; ACIDS;

D O I：

10.3390/md15070230

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel indole, microindolinone A (1), was isolated from a deep-sea-derived actinomycete Microbacterium sp. MCCC 1A11207, together with 18 known compounds (2-19). By detailed analysis of the H-1, C-13, HSQC, COSY, HMBC, high resolution electron spray ionization mass spectrum (HRESIMS), and circular dichroism (CD) data, the absolute configuration of 1 was elucidated as 5R-hydroxy-4,5,6,7-tetrahydroindole-4-one. It is noteworthy that 1 is the second example of a saturated indole isolated from nature.

引用

页数：8

共 35 条

[1] Plant growth promoters isolated from a marine bacterium associated with Palythoa sp. [J].

Cronan, JM ;

Davidson, TR ;

Singleton, FL ;

Colwell, RR ;

Cardellina, JH .

NATURAL PRODUCT LETTERS, 1998, 11 (04) :271-278

[2] C-13 NUCLEAR MAGNETIC-RESONANCE STUDIES OF CONFORMATIONS OF CYCLIC DIPEPTIDES [J].

DESLAURIERS, R ;

GRZONKA, Z ;

SCHAUMBURG, K ;

SHIBA, T ;

WALTER, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (18) :5093-5100

[3] Pyrocoll, an antibiotic, antiparasitic and antitumor compound produced by a novel alkaliphilic Streptomyces strain [J].

Dieter, A ;

Fiedler, HP ;

Goodfellow, M ;

Müller, WEG ;

Brun, R ;

Beil, W ;

Bringmann, G .

JOURNAL OF ANTIBIOTICS, 2003, 56 (07) :639-646

[4] Evolutionary concepts in natural products discovery: what actinomycetes have taught us [J].

Diminic, Janko ;

Starcevic, Antonio ;

Lisfi, Mohamed ;

Baranasic, Damir ;

Gacesa, Ranko ;

Hranueli, Daslav ;

Long, Paul F. ;

Cullum, John ;

Zucko, Jurica .

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2014, 41 (02) :211-217

[5] 1H and 13C NMR assignments of eight nitrogen containing compounds from Nocardia alba sp.nov (YIM 30243T) [J].

Ding, Zhang-Gui ;

Zhao, Jiang-Yuan ;

Yang, Pei-Wen ;

Li, Ming-Gang ;

Huang, Rong ;

Cui, Xiao-Long ;

Wen, Meng-Liang .

MAGNETIC RESONANCE IN CHEMISTRY, 2009, 47 (04) :366-370

[6] Salinosporamide A:: A highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora [J].

Feling, RH ;

Buchanan, GO ;

Mincer, TJ ;

Kauffman, CA ;

Jensen, PR ;

Fenical, W .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (03) :355-+

[7] Identification and characterization of a novel (+)-γ-lactamase from Microbacterium hydrocarbonoxydans [J].

Gao, Shuaihua ;

Huang, Rong ;

Zhu, Shaozhou ;

Li, Hongxia ;

Zheng, Guojun .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2016, 100 (22) :9543-9553

[8] Design and synthesis of a unique ditopic macrocyclic fluorescent receptor containing furan ring as a spacer for the recognition of dicarboxylic acids [J].

Goswami, Shyamaprosad ;

Dey, Swapan ;

Jana, Subrata .

TETRAHEDRON, 2008, 64 (27) :6358-6363

[9]

Gupta L, 2007, CURR MED CHEM, V14, P1789

[10] Diastereoselective alkylation of a proline-derived bicyclic lactim ether [J].

Hendea, Daniela ;

Laschat, Sabine ;

Baro, Angelika ;

Frey, Wolfgang .

HELVETICA CHIMICA ACTA, 2006, 89 (09) :1894-1909

← 1 2 3 4 →