Fabricating Highly Aligned Electrospun Poly(ε-caprolactone) Micro/Nanofibers for Nerve Tissue Regeneration

Recently, an electrospinning process, which is one of various nanotechnologies, has been used in fabricating micro/nanosized fibers. The fabricated electrospun micro/nanofibers has been widely applied in biomedical applications, specially in tissue regeneration. In this study, we fabricated highly aligned electrospun biodegradable and biocompatible poly(epsilon-caprolactone) (PCL) micro/nanofibers by using a modified electrospinning process supplemented with a complex electric field. From this process, we can attain highly aligned electrospun nanofibers compared to that fabricated with the normal electrospinning process. To observe the feasibility of the highly aligned electrospun mat as a biomedical scaffold, nerve cells (PC-12) was cultured and it was found that the cells those were well oriented to the direction of aligned fibers.