The role of intracochlear drug delivery devices in the management of inner ear disease

被引:29
作者
Ayoob, Andrew M. [1 ,2 ,3 ,4 ]
Borenstein, Jeffrey T. [2 ]
机构
[1] Harvard Univ, Cambridge, MA 02138 USA
[2] Draper Lab, Ctr Biomed Engn, Cambridge, MA 02139 USA
[3] Harvard Univ, Sch Med, Program Speech & Hearing Biosci & Technol, Boston, MA USA
[4] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
关键词
drug delivery; hair cells; implantable devices; inner ear; intracochlear; local delivery; microelectronics; microfluidics; regeneration; sensory cells; SENSORINEURAL HEARING-LOSS; MENIERES-DISEASE; COCHLEAR IMPLANTATION; NEUROTROPHIC FACTOR; STEROID PERFUSION; IN-VITRO; GENTAMICIN; DEXAMETHASONE; NANOPARTICLES; THERAPY;
D O I
10.1517/17425247.2015.974548
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Introduction: Diseases of the inner ear include those of the auditory and vestibular systems, and frequently result in disabling hearing loss or vertigo. Despite a rapidly expanding pipeline of potential cochlear therapeutics, the inner ear remains a challenging organ for targeted drug delivery, and new technologies are required to deliver these therapies in a safe and efficacious manner. In addition to traditional approaches for direct inner ear drug delivery, novel microfluidics-based systems are under development, promising improved control over pharmacokinetics over longer periods of delivery, ultimately with application towards hair cell regeneration in humans. Areas covered: Advances in the development of intracochlear drug delivery systems are reviewed, including passive systems, active microfluidic technologies and cochlear prosthesis-mediated delivery. This article provides a description of novel delivery systems and their potential future clinical applications in treating inner ear disease. Expert opinion: Recent progresses in microfluidics and miniaturization technologies are enabling the development of wearable and ultimately implantable drug delivery microsystems. Progress in this field is being spurred by the convergence of advances in molecular biology, microfluidic flow control systems and models for drug transport in the inner ear. These advances will herald a new generation of devices, with near-term applications in preclinical models, and ultimately with human clinical use for a range of diseases of the inner ear.
引用
收藏
页码:465 / 479
页数:15
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