Contrast performance in catalytic ability -: new cinchona phase transfer catalysts for asymmetric synthesis of α-amino acids

被引：14

作者：

Elango, S ^{[1
]}

Venugopal, M ^{[1
]}

Suresh, PS ^{[1
]}

Eni ^{[1
]}

机构：

[1] Inst Chem & Engn Sci, Jurong Isl 627833, Singapore

来源：

TETRAHEDRON | 2005年 / 61卷 / 06期

关键词：

chiral phase transfer catalyst; cinchona alkaloids;

D O I：

10.1016/j.tet.2004.12.005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new cinchona phase transfer catalysts are prepared front dihydrocinchonidine using 13-picenytmethyl bromide and I-pyrenylmethyl bromide, respectively. A total contrast in catalytic efficiency is observed during the asymmetric alkylation of glycinate esters; with one catalyst, the reaction is either incomplete or the enantioselectivity is very poor (15% ee) while the other catalyst afforded high selectivity up to 94% ee. (C) 2004 Elsevier Ltd. All fights reserved.

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收藏

页码：1443 / 1447

页数：5

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