Contrast performance in catalytic ability -: new cinchona phase transfer catalysts for asymmetric synthesis of α-amino acids

被引：14
作者：
Elango, S [1 ]
Venugopal, M [1 ]
Suresh, PS [1 ]
Eni [1 ]
机构：
[1] Inst Chem & Engn Sci, Jurong Isl 627833, Singapore
来源：
TETRAHEDRON | 2005年 / 61卷 / 06期
关键词：
chiral phase transfer catalyst; cinchona alkaloids;
D O I：
10.1016/j.tet.2004.12.005
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two new cinchona phase transfer catalysts are prepared front dihydrocinchonidine using 13-picenytmethyl bromide and I-pyrenylmethyl bromide, respectively. A total contrast in catalytic efficiency is observed during the asymmetric alkylation of glycinate esters; with one catalyst, the reaction is either incomplete or the enantioselectivity is very poor (15% ee) while the other catalyst afforded high selectivity up to 94% ee. (C) 2004 Elsevier Ltd. All fights reserved.
引用
收藏
页码：1443 / 1447
页数：5
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