High-intensity resistance training attenuates dexamethasone-induced muscle atrophy

被引：33

作者：

Krug, Andre L. O. ^{[1
]}

Macedo, Anderson G. ^{[1
]}

Zago, Anderson S. ^{[2
]}

Rush, James W. E. ^{[3
]}

Santos, Carlos F. ^{[4
]}

Amaral, Sandra L. ^{[1
,2
]}

机构：

[1] Sao Paulo State Univ, Univ Fed Sao Carlos, PIPGCF UFscar UNESP, Joint Grad Program Physiol Sci, Sao Paulo, Brazil

[2] Sao Paulo State Univ, Fac Sci, Dept Phys Educ, Ave Eng Luiz Edmundo Carrijo Coube, Sao Paulo, Brazil

[3] Univ Waterloo, Dept Kinesiol, Fac Appl Hlth Sci, Waterloo, ON N2L 3G1, Canada

[4] Univ Sao Paulo, Dept Biol Sci, Bauru Sch Dent, Sao Paulo, Brazil

来源：

MUSCLE & NERVE | 2016年 / 53卷 / 05期

基金：

巴西圣保罗研究基金会;

关键词：

glucocorticoids; ladder climbing; muscle atrophy; resistance training; skeletal muscle; INSULIN-RESISTANCE; EXPRESSION; EXERCISE; ATROGIN-1; GLUCOCORTICOIDS; HYPERTROPHY; SARCOPENIA; LEPTIN; GROWTH; MURF1;

D O I：

10.1002/mus.24906

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IntroductionIn this study we investigated the effects of high-intensity resistance training (RT) on dexamethasone (DEX)-induced muscle atrophy in flexor hallucis longus (FHL), tibialis anterior (TA), and soleus (SOL) muscles. Methods: Rats underwent either high-intensity RT or were kept sedentary. In the last 10 days they received either DEX (0.5mg/kg/day, intraperitoneally) or saline. Results: DEX reduced body weight (-21%), food intake (-28%), FHL and TA muscle mass (-20% and -18%, respectively), and increased muscle-specific ring finger 1 (MuRF-1) protein level (+37% and +45.5%). RT attenuated FHL muscle atrophy through a combination of low increase in MuRF-1 protein level (-3.5%) and significant increases in mammalian target of rapamycin (mTOR) (+63%) and p70S6K (+46% and +49% for control and DEX, respectively) protein levels. Conclusion: RT attenuated DEX-induced muscle atrophy through a combination of increases in mTOR and p70S6K protein levels and a low increase in MuRF-1 protein level. Muscle Nerve53: 779-788, 2016

引用

页码：779 / 788

页数：10

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