Hepatitis Delta Virus RNA Replication

被引：38

作者：

Tseng, Chung-Hsin ^{[1
]}

Lai, Michael M. C. ^{[1
,2
,3
]}

机构：

[1] Acad Sinica, Inst Mol Biol, Taipei 115, Taiwan

[2] Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA

[3] Natl Cheng Kung Univ, Tainan 701, Taiwan

来源：

VIRUSES-BASEL | 2009年 / 1卷 / 03期

关键词：

hepatitis delta virus; hepatitis delta antigen; RNA-dependent RNA synthesis; RNA polymerases; RNA replication; POLYMERASE-II; ANTIGENOMIC RNA; MESSENGER-RNA; GENOME REPLICATION; BINDING-ACTIVITY; B-VIRUS; TRANSCRIPTION; EXPRESSION; NUCLEUS; AGENT;

D O I：

10.3390/v1030818

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis delta virus (HDV) is a distant relative of plant viroids in the animal world. Similar to plant viroids, HDV replicates its circular RNA genome using a double rolling-circle mechanism. Nevertheless, the production of hepatitis delta antigen ( HDAg), which is indispensible for HDV replication, is a unique feature distinct from plant viroids, which do not encode any protein. Here the HDV RNA replication cycle is reviewed, with emphasis on the function of HDAg in modulating RNA replication and the nature of the enzyme involved.

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收藏

页码：818 / 831

页数：14

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