Anti-Inflammatory and Immunomodulatory Mechanism of Tanshinone IIA for Atherosclerosis

被引：43

作者：

Chen, Zhuo ^{[1
]}

Xu, Hao ^{[2
]}

机构：

[1] Beijing Univ Chinese Med, Grad Sch, Beijing 100029, Peoples R China

[2] China Acad Chinese Med Sci, Cardiovasc Dis Ctr, Xiyuan Hosp, Beijing 100091, Peoples R China

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2014年 / 2014卷

基金：

中国国家自然科学基金;

关键词：

NF-KAPPA-B; TNF-ALPHA; OXIDATIVE STRESS; EXPRESSION; INHIBITION; VCAM-1; ICAM-1; CELLS; DIET; INFLAMMATION;

D O I：

10.1155/2014/267976

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Tanshinone IIA (Tan II A) is widely used in the treatment of cardiovascular diseases as an active component of Salvia miltiorrhiza Bunge. It has been demonstrated to have pleiotropic effects for atherosclerosis. From the anti-inflammatory and immunomodulatory mechanism perspective, this paper reviewed major progresses of Tan IIA in antiatherosclerosis research, including immune cells, antigens, cytokines, and cell signaling pathways.

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