A Mouse Model of Melanoma Driven by Oncogenic KRAS

被引：57

作者：

Milagre, Carla ^{[1
]}

Dhomen, Nathalie ^{[1
]}

Geyer, Felipe C. ^{[2
]}

Hayward, Robert ^{[1
]}

Lambros, Maryou ^{[2
]}

Reis-Filho, Jorge S. ^{[2
]}

Marais, Richard ^{[1
]}

机构：

[1] Inst Canc Res, Signal Transduct Team, London SW3 6JB, England

[2] Inst Canc Res, Mol Pathol Breakthrough Breast Canc Res Ctr, London SW3 6JB, England

来源：

CANCER RESEARCH | 2010年 / 70卷 / 13期

关键词：

K-RAS; TUMOR; GENE; ACTIVATION; MUTATIONS; PATHWAYS; CANCER; BRAF;

D O I：

10.1158/0008-5472.CAN-09-4254

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The small G-protein NRAS is mutated in 22% of human melanomas, whereas the related proteins KRAS and HRAS are mutated in only 2% and 1% of melanomas, respectively. We have developed a mouse model of melanoma in which Cre recombinase/LoxP technology is used to drive inducible expression of (G12V)KRAS in the melanocytic lineage. The mice develop skin hyperpigmentation, nevi, and tumors that bear many of the cardinal histopathology features and molecular characteristics of human melanoma. These tumors invade and destroy the underlying muscles and cells derived from them can grow as subcutaneous tumors and colonize the lungs of nude mice. These data establish that oncogenic KRAS can be a founder event in melanomagenesis. Cancer Res; 70(13); 5549-57. (C)2010 AACR.

引用

页码：5549 / 5557

页数：9

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