Antioxidant activity of some ascorbic and cinnamic acids derivatives

被引：7

作者：

Point, D

Coudert, P

Leal, F

Rubat, C

Sautou-Miranda, V

Chopineau, J

Couquelet, J

机构：

[1] Fac Pharm Clermont Ferrand, Grp Rech Pharmacochim, Chim Therapeut Lab, F-63001 Clermont Ferrand, France

[2] Fac Pharm Clermont Ferrand, Lab Pharm Clin & Biotech, F-63001 Clermont Ferrand, France

[3] Fac Pharm Clermont Ferrand, Pharmacol Lab, F-63001 Clermont Ferrand, France

来源：

FARMACO | 1998年 / 53卷 / 01期

关键词：

ascorbic acid derivatives; cinnamic acid derivatives; furan-2-ones derivatives; antioxidant activity;

D O I：

10.1016/S0014-827X(97)00012-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Some 4-benzoyl 3-hydroxy furan-2 (5H) ones (3a-d) and 2-amino 3-hydroxymethyl 4-aryl 4-oxo 2-butenoic acids (4a-h) have been synthesized. Compound 3c with an isobutyl substituent in the 5-position of the furan ring was the most effective (IC50 = 8.69 X 10(-4) M) in scavenging the superoxide anion. In vivo, 3c was also protective against reperfusion injury. (C) 1998 Elsevier Science S.A.

引用

收藏

页码：85 / 88

页数：4

相关论文

共 10 条

[1] OXIDANTS AND ANTIOXIDANTS - STATE-OF-THE-ART [J].

BAST, A ;

HAENEN, GRMM ;

DOELMAN, CJA .

AMERICAN JOURNAL OF MEDICINE, 1991, 91 :S2-S13

[2] EVALUATION OF FREE-RADICAL PRODUCTION IN AN ISCHEMIA-REPERFUSION MODEL IN THE RABBIT USING A TOURNIQUET [J].

CHOPINEAU, J ;

SOMMIER, MF ;

SAUTOU, V .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1994, 46 (06) :519-520

[3]

Coudert P, 1996, BIOL PHARM BULL, V19, P220

[4] INFLUENCE OF CATIONIC AMPHIPHILIC DRUGS ON THE CHARACTERISTICS OF OUABAIN-BINDING TO CARDIAC NA+/K+-ATPASE [J].

DUNST, J ;

LULLMANN, H ;

MOHR, K .

BIOCHEMICAL PHARMACOLOGY, 1983, 32 (10) :1595-1600

[5]

DURANTIN G, 1972, CHIM THER, V6, P472

[6] INHIBITION OF HUMAN LOW-DENSITY-LIPOPROTEIN OXIDATION BY CAFFEIC ACID AND OTHER HYDROXYCINNAMIC ACID-DERIVATIVES [J].

NARDINI, M ;

DAQUINO, M ;

TOMASSI, G ;

GENTILI, V ;

DIFELICE, M ;

SCACCINI, C .

FREE RADICAL BIOLOGY AND MEDICINE, 1995, 19 (05) :541-552

[7] 3-0-ALKYLASCORBIC ACIDS AS FREE-RADICAL QUENCHERS .3. PROTECTIVE EFFECT ON CORONARY-OCCLUSION REPERFUSION INDUCED ARRHYTHMIAS IN ANESTHETIZED RATS [J].

NIHRO, Y ;

SOGAWA, S ;

IZUMI, A ;

SASAMORI, A ;

SUDO, T ;

MIKI, T ;

MATSUMOTO, H ;

SATOH, T .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (09) :1618-1623

[8] ANTIOXIDANT AND NEUTROPHIL-INHIBITING PROPERTIES OF NEW 2-O-METHYL-6-(ALKYLTHIO)ASCORBIC ACID-DERIVATIVES [J].

SCHMID, E ;

FIGALA, V ;

ROTH, D ;

ULLRICH, V .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (25) :4021-4029

[9]

SLATER TF, 1974, INT S TIRRENIA, P84

[10]

TANI E, 1994, ARZNEIMITTELFORSCH, V44-2, P992