A NEW XANTHONE AND ANTI-INFLAMMATORY CONSTITUENTS OF Garcinia subelliptica

被引：5

作者：

Chen, Jih-Jung ^{[1
,2
]}

Hung, Ming-Chi ^{[3
]}

Liao, Hsiang-Ruei ^{[4
]}

Kuo, Yueh-Hsiung ^{[5
]}

Shu, Chih-Wen ^{[6
]}

Sung, Ping-Jyun ^{[7
]}

Lim, Yun-Ping ^{[8
]}

Kuo, Wen-Lung ^{[9
]}

Cheng, Lin-Yang ^{[10
]}

Wang, Sin-Ling ^{[10
]}

Wu, Jui-Jen ^{[11
]}

机构：

[1] Natl Yang Ming Univ, Sch Pharmaceut Sci, Fac Pharm, Taipei 112, Taiwan

[2] China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan

[3] Tajen Univ, Dept Pharm, Pingtung 907, Taiwan

[4] Chang Gung Univ, Coll Med, Sch Tradit Chinese Med, Grad Inst Nat Prod, Taoyuan 333, Taiwan

[5] China Med Univ, Dept Chinese Pharmaceut Sci & Chinese Med Resourc, Taichung 404, Taiwan

[6] Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, Kaohsiung 813, Taiwan

[7] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[8] China Med Univ, Coll Pharm, Sch Pharm, Taichung 404, Taiwan

[9] Chung Jen Jr Coll Nursing Hlth Sci & Management, Chiayi 600, Taiwan

[10] Kaohsiung Med Univ, Coll Pharm, Sch Pharm, Taichung 807, Taiwan

[11] Natl Taichung First Senior High Sch, Taichung 404, Taiwan

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2017年 / 53卷 / 04期

关键词：

Garcinia subelliptica; Guttiferae; root; xanthone; garcisubellone; anti-inflammatory activity; PRO-INFLAMMATORY RESPONSES; MULTIFLORA; BIPHENYLS; LINII; ROOT;

D O I：

10.1007/s10600-017-2082-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new xanthone, garcisubellone (1), has been isolated from the roots of Garcinia subelliptica, together with three known compounds, subelliptenone E (2), 1,5-dihydroxy-3-methoxyxanthone (3), and 1,4,5-trihydroxyxanthone (4). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Garcisubellone (1) and 1,4,5-trihydroxyxanthone (4) exhibited potent inhibition, with IC50 values of 18.3 +/- 2.2 and 15.6 +/- 2.8 mu M, respectively, against formyl-L-methionyl-L-leucyl-Lphenylalanine (fMLP)-induced superoxide anion (O-2 center dot(-)) generation.

引用

页码：649 / 652

页数：4

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