Cerebrovascular Alterations in Alzheimer Disease Incidental or Pathogenic?

被引：101

作者：

Iadecola, Costantino ^{[1
]}

Gottesman, Rebecca F. ^{[2
]}

机构：

[1] Feil Family Brain & Mind Res Inst, Weill Cornell Med, 407 E 61st St,RR-303, New York, NY 10065 USA

[2] Johns Hopkins Univ, Dept Neurol & Epidemiol, Baltimore, MD USA

来源：

CIRCULATION RESEARCH | 2018年 / 123卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Alzheimer disease; blood-brain barrier; dementia; neurons; risk factors; VASCULAR RISK-FACTORS; ATHEROSCLEROSIS RISK; DEMENTIA;

D O I：

10.1161/CIRCRESAHA.118.313400

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Alzheimer disease (AD)-the leading cause of cognitive impairment in the elderly-has traditionally been considered a disease of neurons. Structural and functional alterations of cerebral blood vessels also occur, but direct evidence of a causal involvement in the pathobiology of the disease has been lacking. This viewpoint will review new data that may help shed light into the intriguing association between vascular and neurodegenerative pathology.

引用

页码：406 / 408

页数：3

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