Cerebrovascular Alterations in Alzheimer Disease Incidental or Pathogenic?

被引：97
作者：
Iadecola, Costantino [1 ]
Gottesman, Rebecca F. [2 ]
机构：
[1] Feil Family Brain & Mind Res Inst, Weill Cornell Med, 407 E 61st St,RR-303, New York, NY 10065 USA
[2] Johns Hopkins Univ, Dept Neurol & Epidemiol, Baltimore, MD USA
来源：
CIRCULATION RESEARCH | 2018年 / 123卷 / 04期
基金：
美国国家卫生研究院;
关键词：
Alzheimer disease; blood-brain barrier; dementia; neurons; risk factors; VASCULAR RISK-FACTORS; ATHEROSCLEROSIS RISK; DEMENTIA;
D O I：
10.1161/CIRCRESAHA.118.313400
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Alzheimer disease (AD)-the leading cause of cognitive impairment in the elderly-has traditionally been considered a disease of neurons. Structural and functional alterations of cerebral blood vessels also occur, but direct evidence of a causal involvement in the pathobiology of the disease has been lacking. This viewpoint will review new data that may help shed light into the intriguing association between vascular and neurodegenerative pathology.
引用
收藏
页码：406 / 408
页数：3
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  • [1] Concomitant vascular and neurodegenerative pathologies double the risk of dementia
    Azarpazhooh, Mahmoud Reza
    Avan, Abolfazl
    Cipriano, Lauren E.
    Munoz, David G.
    Sposato, Luciano A.
    Hachinski, Vladimir
    [J]. ALZHEIMERS & DEMENTIA, 2018, 14 (02) : 148 - 156
  • [2] Lesion location and cognitive impact of cerebral small vessel disease
    Biesbroek, J. Matthijs
    Weaver, Nick A.
    Biessels, Geert Jan
    [J]. CLINICAL SCIENCE, 2017, 131 (08) : 715 - 728
  • [3] Alzheimer disease and risk of stroke A population-based cohort study
    Chi, Nai-Fang
    Chien, Li-Nien
    Ku, Hsiao-Lun
    Hu, Chaur-Jong
    Chiou, Hung-Yi
    [J]. NEUROLOGY, 2013, 80 (08) : 705 - 711
  • [4] The Cellular Phase of Alzheimer's Disease
    De Strooper, Bart
    Karran, Eric
    [J]. CELL, 2016, 164 (04) : 603 - 615
  • [5] Intracranial atherosclerosis and dementia The Atherosclerosis Risk in Communities (ARIC) Study
    Dearborn, Jennifer L.
    Zhang, Yiyi
    Qiao, Ye
    Suri, Muhammad Fareed K.
    Liu, Li
    Gottesman, Rebecca F.
    Rawlings, Andreea M.
    Mosley, Thomas H.
    Alonso, Alvaro
    Knopman, David S.
    Guallar, Eliseo
    Wasserman, Bruce A.
    [J]. NEUROLOGY, 2017, 88 (16) : 1556 - 1563
  • [6] Risk of incident clinical diagnosis of Alzheimer's disease-type dementia attributable to pathology-confirmed vascular disease
    Dodge, Hiroko H.
    Zhu, Jian
    Woltjer, Randy
    Nelson, Peter T.
    Bennett, David A.
    Cairns, Nigel J.
    Fardo, David W.
    Kaye, Jeffrey A.
    Lyons, Deniz-Erten
    Mattek, Nora
    Schneider, Julie A.
    Silbert, Lisa C.
    Xiong, Chengjie
    Yu, Lei
    Schmitt, Frederick A.
    Kryscio, Richard J.
    Abner, Erin L.
    [J]. ALZHEIMERS & DEMENTIA, 2017, 13 (06) : 613 - 623
  • [7] Association Between Vascular Pathology and Rate of Cognitive Decline Independent of Alzheimer's Disease Pathology
    Ezzati, Ali
    Wang, Cuiling
    Lipton, Richard B.
    Altschul, Dorothea
    Katz, Mindy J.
    Dickson, Dennis W.
    Derby, Carol A.
    [J]. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2017, 65 (08) : 1836 - 1841
  • [8] Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial
    Forette, F
    Seux, ML
    Staessen, JA
    Thijs, L
    Birkenhäger, WH
    Babarskiene, MR
    Babeanu, S
    Bossini, A
    Gil-Extremera, B
    Girerd, X
    Laks, T
    Lilov, E
    Moisseyev, V
    Tuomilehto, J
    Vanhanen, H
    Webster, J
    Yodfat, Y
    Fagard, R
    [J]. LANCET, 1998, 352 (9137) : 1347 - 1351
  • [9] Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort
    Gottesman, Rebecca F.
    Albert, Marilyn S.
    Alonso, Alvaro
    Coker, Laura H.
    Coresh, Josef
    Davis, Sonia M.
    Deal, Jennifer A.
    McKhann, Guy M.
    Mosley, Thomas H.
    Sharrett, A. Richey
    Schneider, Andrea L. C.
    Windham, B. Gwen
    Wruck, Lisa M.
    Knopman, David S.
    [J]. JAMA NEUROLOGY, 2017, 74 (10) : 1246 - 1254
  • [10] Association Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition
    Gottesman, Rebecca F.
    Schneider, Andrea L. C.
    Zhou, Yun
    Coresh, Josef
    Green, Edward
    Gupta, Naresh
    Knopman, David S.
    Mintz, Akiva
    Rahmim, Arman
    Sharrett, A. Richey
    Wagenknecht, Lynne E.
    Wong, Dean F.
    Mosley, Thomas H.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2017, 317 (14): : 1443 - 1450
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