Antiviral therapy of primary cytomegalovirus infection with vascular thrombosis in immunocompetent adults

被引:11
作者
Deconinck, L. [1 ,2 ]
Flateau, C. [3 ]
Pichenot, M. [1 ,4 ]
Morell-Dubois, S. [4 ]
Maillard, H. [4 ]
Hatron, P. -Y. [4 ]
Guery, B. [1 ]
Faure, K. [1 ]
机构
[1] CHU Lille, Serv Malad Infect & Trop, 2 Ave Oscar Lambret, F-59000 Lille, France
[2] Ctr Hosp Tourcoing, Serv Malad Infect & Trop, 155 Rue President Coty, F-59200 Tourcoing, France
[3] Hop Mil Begin, Serv Malad Infect & Trop, 69 Ave Paris, F-94160 St Mande, France
[4] CHU Lille, Serv Med Interne, 2 Ave Oscar Lambret, F-59000 Lille, France
来源
MEDECINE ET MALADIES INFECTIEUSES | 2016年 / 46卷 / 02期
关键词
Cytomegalovirus; Thrombosis; Antiviral therapy; RETINAL VEIN OCCLUSION; PATIENT; RETINITIS;
D O I
10.1016/j.medmal.2015.12.013
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background. -Vascular thromboembolism (VTE) complicating cytomegalovirus (CMV) primary infection is increasingly reported in immunocompetent adults. No guideline is, however, currently available for the management of these infections and particularly for the antiviral therapy indication. Methods. -We performed a literature review of VTE complicating CMV primary infection in immunocompetent adults using PubMed. Results. -Sixty-nine case patients of VTE complicating CMV primary infection were reported. The main sites of venous thrombosis were the splanchnic veins (30 patients) or those of the lower limbs (18 patients). One-third of patients presented with pulmonary embolism (25 patients). Forty-nine patients (76%) had at least one VTE risk factor, inherited or acquired thrombophilia for 37 patients (58%), and another risk factor for 27 patients (42%). Only 11 patients received an antiviral therapy. A positive outcome was observed in all patients. Conclusion. -We suggest that antiviral therapy should be considered for patients presenting with severe VTE, VTE with a negative outcome despite anticoagulation, severe organ involvement, or for patients managed in the intensive care unit. (C) 2016 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:87 / 92
页数:6
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