Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation

被引：57

作者：

Olesch, Catherine ^{[1
]}

Ringel, Christian ^{[1
]}

Bruene, Bernhard ^{[1
]}

Weigert, Andreas ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Inst Biochem 1, Fac Med, D-60590 Frankfurt, Germany

来源：

MEDIATORS OF INFLAMMATION | 2017年 / 2017卷

关键词：

PLASMACYTOID DENDRITIC CELLS; IFN-ALPHA PRODUCTION; SPHINGOSINE KINASE 2; CERAMIDE SYNTHASE 2; LYMPH-NODES; ACTIN DYNAMICS; T(H)17 CELLS; SAR ANALYSIS; 1-PHOSPHATE; TRAFFICKING;

D O I：

10.1155/2017/6059203

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The sphingolipid sphingosine-1-phosphate (S1P) emerges as an important regulator of immunity, mainly by signaling through a family of five specific G protein-coupled receptors (S1PR1-5). While S1P signaling generally has the potential to affect not only trafficking but also differentiation, activation, and survival of a diverse range of immune cells, the specific outcome depends on the S1P receptor repertoire expressed on a given cell. Among the S1PRs, S1PR4 is specifically abundant in immune cells, suggesting a major role of the S1P/S1PR4 axis in immunity. Recent studies indeed highlight its role in activation of immune cells, differentiation, and, potentially, trafficking. In this review, we summarize the emerging data that support a major role of S1PR4 in modulating immunity in humans and mice and discuss therapeutic implications.

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页数：12

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