Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation

被引：57
作者：
Olesch, Catherine [1 ]
Ringel, Christian [1 ]
Bruene, Bernhard [1 ]
Weigert, Andreas [1 ]
机构：
[1] Goethe Univ Frankfurt, Inst Biochem 1, Fac Med, D-60590 Frankfurt, Germany
来源：
MEDIATORS OF INFLAMMATION | 2017年 / 2017卷
关键词：
PLASMACYTOID DENDRITIC CELLS; IFN-ALPHA PRODUCTION; SPHINGOSINE KINASE 2; CERAMIDE SYNTHASE 2; LYMPH-NODES; ACTIN DYNAMICS; T(H)17 CELLS; SAR ANALYSIS; 1-PHOSPHATE; TRAFFICKING;
D O I：
10.1155/2017/6059203
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The sphingolipid sphingosine-1-phosphate (S1P) emerges as an important regulator of immunity, mainly by signaling through a family of five specific G protein-coupled receptors (S1PR1-5). While S1P signaling generally has the potential to affect not only trafficking but also differentiation, activation, and survival of a diverse range of immune cells, the specific outcome depends on the S1P receptor repertoire expressed on a given cell. Among the S1PRs, S1PR4 is specifically abundant in immune cells, suggesting a major role of the S1P/S1PR4 axis in immunity. Recent studies indeed highlight its role in activation of immune cells, differentiation, and, potentially, trafficking. In this review, we summarize the emerging data that support a major role of S1PR4 in modulating immunity in humans and mice and discuss therapeutic implications.
引用
收藏
页数：12
相关论文
共 103 条
[1]   Sphingosine-1-phosphate Lyase Deficiency Produces a Pro-inflammatory Response While Impairing Neutrophil Trafficking [J].
Allende, Maria L. ;
Bektas, Meryem ;
Lee, Bridgin G. ;
Bonifacino, Eliana ;
Kang, Jiman ;
Tuymetova, Galina ;
Chen, WeiPing ;
Saba, Julie D. ;
Proia, Richard L. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (09) :7348-7358
[2]   Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2 [J].
Alvarez, Sergio E. ;
Harikumar, Kuzhuvelil B. ;
Hait, Nitai C. ;
Allegood, Jeremy ;
Strub, Graham M. ;
Kim, Eugene Y. ;
Maceyka, Michael ;
Jiang, Hualiang ;
Luo, Cheng ;
Kordula, Tomasz ;
Milstien, Sheldon ;
Spiegel, Sarah .
NATURE, 2010, 465 (7301) :1084-U149
[3]   Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils [J].
Barthelmes, Julia ;
de Bazo, Anika Maenner ;
Pewzner-Jung, Yael ;
Schmitz, Katja ;
Mayer, Christoph A. ;
Foerch, Christian ;
Eberle, Max ;
Tafferner, Nadja ;
Ferreiros, Nerea ;
Henke, Marina ;
Geisslinger, Gerd ;
Futerman, Anthony H. ;
Grosch, Sabine ;
Schiffmann, Susanne .
BRAIN BEHAVIOR AND IMMUNITY, 2015, 46 :280-292
[4]   Targeting the IL-17-TH17 pathway [J].
Bartlett, Hilary S. ;
Million, Ryan P. .
NATURE REVIEWS DRUG DISCOVERY, 2015, 14 (01) :11-12
[5]   T cell-intrinsic S1PR1 regulates endogenous effector T-cell egress dynamics from lymph nodes during infection [J].
Benechet, Alexandre P. ;
Menon, Manisha ;
Xu, Daqi ;
Samji, Tasleem ;
Maher, Leigh ;
Murooka, Thomas T. ;
Mempel, Thorsten R. ;
Sheridan, Brian S. ;
Lemoine, Francois M. ;
Khanna, Kamal M. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (08) :2182-2187
[6]   HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation [J].
Blaho, Victoria A. ;
Galvani, Sylvain ;
Engelbrecht, Eric ;
Liu, Catherine ;
Swendeman, Steven L. ;
Kono, Mari ;
Proia, Richard L. ;
Steinman, Lawrence ;
Han, May H. ;
Hla, Timothy .
NATURE, 2015, 523 (7560) :342-+
[7]   An update on the biology of sphingosine 1-phosphate receptors [J].
Blaho, Victoria A. ;
Hla, Timothy .
JOURNAL OF LIPID RESEARCH, 2014, 55 (08) :1596-1608
[8]   TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation [J].
Cencetti, Francesca ;
Bernacchioni, Caterina ;
Tonelli, Francesca ;
Roberts, Edward ;
Donati, Chiara ;
Bruni, Paola .
FASEB JOURNAL, 2013, 27 (11) :4532-4546
[9]   Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies [J].
Cho, Judy H. ;
Feldman, Marc .
NATURE MEDICINE, 2015, 21 (07) :730-738
[10]   Follicular shuttling of marginal zone B cells facilitates antigen transport [J].
Cinamon, Guy ;
Zachariah, Marcus A. ;
Lam, Olivia M. ;
Foss, Frank W., Jr. ;
Cyster, Jason G. .
NATURE IMMUNOLOGY, 2008, 9 (01) :54-62
12345678910