Virginols A-C, three new withanolides from Physalis virginiana

被引：15
|
作者：
Maldonado, Emma [1 ]
Amador, Sonia [1 ]
Martinez, Mahinda [2 ]
Perez-Castorena, Ana L. [1 ]
机构：
[1] Univ Nacl Autonoma Mexico, Inst Quim, Coyoacan 04510, DF, Mexico
[2] Univ Autonoma Queretaro, Fac Ciencias Nat, Queretaro, Mexico
来源：
STEROIDS | 2010年 / 75卷 / 4-5期
关键词：
Withasteroids; 16; alpha-Acetoxywithanolides; Physalis virginiana; Anti-inflammatory activity; PRINCIPLES;
D O I：
10.1016/j.steroids.2010.01.014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Virginols A-C are three new withanolides containing an epoxylactol at the side chain. They were isolated from the aerial parts of Physalis virginiana Miller. Structures of these compounds were determined by analyses of their spectroscopic data, including 1D and 2D NMR. The structure of virginol A was confirmed by X-ray diffraction analysis. The anti-inflammatory activity of virginols was evaluated in the TPA-induced ear mouse edema model. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：346 / 349
页数：4
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