Molecular Determinants of Flavivirus Virion Assembly

被引：70

作者：

Barnard, Trisha R. ^{[1
]}

Abram, Quinn H. ^{[2
]}

Lin, Qi Feng ^{[2
]}

Wang, Alex B. ^{[1
]}

Sagan, Selena M. ^{[1
,2
]}

机构：

[1] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ H3G 1Y6, Canada

[2] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2021年 / 46卷 / 05期

基金：

加拿大自然科学与工程研究理事会;

关键词：

assembly; capsid; dengue virus; nonstructural protein 2A (NS2A); NS2B-NS3; packaging; yellow fever virus; Zika virus;

D O I：

10.1016/j.tibs.2020.12.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Virion assembly is an important step in the life cycle of all viruses. For viruses of the Flavivirus genus, a group of enveloped positive-sense RNA viruses, the assembly step represents one of the least understood processes in the viral life cycle. While assembly is primarily driven by the viral structural proteins, recent studies suggest that several nonstructural proteins also play key roles in coordinating the assembly and packaging of the viral genome. This review focuses on describing recent advances in our understanding of flavivirus virion assembly, including the intermolecular interactions between the viral structural (capsid) and nonstructural proteins (NS2A and NS2B-NS3), host factors, as well as features of the viral genomic RNA required for efficient flavivirus virion assembly.

引用

页码：378 / 390

页数：13

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