WIN55,212-2 via CB2 receptor attenuates TNF-α and ROS in RAW264.7 macrophages by activating ERK1/2 signaling

被引:0
|
作者
Hao, Ming-Xiu [1 ]
Jiang, Li-Sheng [2 ]
Fang, Ning-Yuan [1 ]
He, Ben [2 ]
机构
[1] Shanghai Jiao Tong Univ, Dept Geriatr, Ren Ji Hosp, Sch Med, Shanghai 200030, Peoples R China
[2] Shanghai Jiao Tong Univ, Dept Cardiol, Ren Ji Hosp, Sch Med, Shanghai 200030, Peoples R China
关键词
D O I
10.1016/j.ijcard.2009.09.020
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:S6 / S6
页数:1
相关论文
共 50 条
  • [1] ANTIINFLAMMATORY ACTIVITY OF WIN55,212-2, A NONSELECTIVE CANNABINOID CB1/CB2 RECEPTOR AGONIST
    Bradley, Jennifer
    Wang Yanyan
    Jankovic, Lazar
    Huang, Iris
    Sharma, Esha
    Moore, Christine
    Peberdy, Mary
    Ornato, Joseph
    Tang, Wanc-Hun
    Zhou, Huiping
    CRITICAL CARE MEDICINE, 2020, 48
  • [2] Adiponectin increases TNF-α expression in RAW264.7 macrophages via ERK1/2 activation and EGR-11 expression
    Park, P.
    McMullen, M. R.
    Thakur, V.
    Nagy, L. E.
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2007, 31 (06) : 216A - 216A
  • [3] The synthetic cannabinoid agonist WIN 55,212-2 reduces experimental pruritus via CB2 receptor activation
    Reck, Antonio Matt
    Siderovski, David P.
    Kinsey, Steven G.
    NEUROPHARMACOLOGY, 2025, 264
  • [4] PKCε Regulates Behavioral Sensitivity, Binding and Tolerance to the CB1 Receptor Agonist WIN55,212-2
    Wallace, Melisa J.
    Newton, Philip M.
    McMahon, Thomas
    Connolly, Jacklyn
    Huibers, Anne
    Whistler, Jennifer
    Messing, Robert O.
    NEUROPSYCHOPHARMACOLOGY, 2009, 34 (07) : 1733 - 1742
  • [5] PKCɛ Regulates Behavioral Sensitivity, Binding and Tolerance to the CB1 Receptor Agonist WIN55,212-2
    Melisa J Wallace
    Philip M Newton
    Thomas McMahon
    Jacklyn Connolly
    Anne Huibers
    Jennifer Whistler
    Robert O Messing
    Neuropsychopharmacology, 2009, 34 : 1733 - 1742
  • [6] Effect of acute and subchronic administration of (R)-WIN55,212-2 induced neuroprotection and anti inflammatory actions in rat retina: CB1 and CB2 receptor involvement
    Spyridakos, Dimitris
    Papadogkonaki, Sofia
    Dionysopoulou, Stavroula
    Mastrodimou, Niki
    Polioudaki, Hara
    Thermos, Kyriaki
    NEUROCHEMISTRY INTERNATIONAL, 2021, 142
  • [7] WIN55,212-2 impairs non-associative recognition and spatial memory in rats via CB1 receptor stimulation
    Galanopoulos, A.
    Polissidis, A.
    Georgiadou, G.
    Papadopoulou-Daifoti, Z.
    Nomikos, G. G.
    Pitsikas, N.
    Antoniou, K.
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2014, 124 : 58 - 66
  • [8] The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB2, TRPV1, TRPA1 and yet unidentified receptor targets
    Lowin, Torsten
    Pongratz, Georg
    Straub, Rainer H.
    JOURNAL OF INFLAMMATION-LONDON, 2016, 13
  • [9] The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins
    Lauckner, JE
    Hille, B
    Mackie, K
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (52) : 19144 - 19149
  • [10] The CB1/CB2 receptor agonist WIN-55,212-2 reduces viability of human Kaposi's sarcoma cells in vitro
    Luca, Tonia
    Di Benedetto, Giulia
    Scuderi, Mariagrazia Rita
    Palumbo, Marco
    Clementi, Silvia
    Bernardini, Renato
    Cantarella, Giuseppina
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2009, 616 (1-3) : 16 - 21