Impaired interienkin-2 production in T-cells from a patient with Wiskott-Aldrich syndrome: basis of clinical effect of interleukin-2 replacement therapy

被引：17

作者：

Azuma, H

Oshima, M

Ito, K

Okuno, A

Kawabata, I

Banba, K

Murahashi, H

Sekine, T

Kato, Y

Ikebuchi, K

Ikeda, H

机构：

[1] Hokkaido Red Cross Blood Ctr, Nishi Ku, Sapporo, Hokkaido 0630002, Japan

[2] Asahikawa Med Coll, Dept Paediat, Asahikawa, Hokkaido 078, Japan

[3] Asahikawa Med Coll, Dept Clin Med, Asahikawa, Hokkaido 078, Japan

[4] Hitachi Kasei, Tokyo, Japan

[5] Nissho Corp, Shiga, Japan

[6] Int Canc Ctr Lab, Tokyo, Japan

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 2000年 / 159卷 / 08期

关键词：

Replacement Therapy; Clinical Effect;

D O I：

10.1007/PL00008395

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Interleukin-2 production may be one of the underlying causes of Wiskott-Aldrich syndrome immunodeficiency and recombinant interleukin-2 administration (or an infusion of T-cells expanded by CD3 stimulation and rIL-2) is able, to some extent, to restore defective T-cell function.

引用

页码：633 / 634

页数：2

共 4 条

[1] EFFECT OF INTERLEUKIN-2 ON INTRACTABLE HERPES-VIRUS INFECTION AND CHRONIC ECZEMATOID DERMATITIS IN A PATIENT WITH WISKOTT-ALDRICH SYNDROME [J].