Signal transducer and activator of transcription 5 (STAT5)

被引：67
作者：
Buitenhuis, M [1 ]
Coffer, PJ [1 ]
Koenderman, L [1 ]
机构：
[1] Univ Utrecht, Med Ctr, Dept Pulm Dis, NL-3584 CX Utrecht, Netherlands
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2004年 / 36卷 / 11期
关键词：
STAT5; cytokines; signal transduction; hematopoiesis;
D O I：
10.1016/j.biocel.2003.11.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Signal transducer and activator of transcription 5 (STAT5) activity is induced by a plethora of cytokines and growth factors resulting in transcriptional activation of specific target genes. STAT5 plays an important role in a variety of cellular processes, including proliferation, differentiation, and apoptosis. Aberrant regulation of STAT5 has been observed in solid tumors as well as in patients with either chronic or acute myeloid leukemia. Kinase inhibitors are currently being developed to negatively regulate STAT5 activity for clinical purposes. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2120 / 2124
页数：5
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