CD4+CD45RO+CD49dhigh cells are involved in the pathogenesis of relapsing-remitting multiple sclerosis

被引：16

作者：

Barrau, MA ^{[1
]}

Montalban, X ^{[1
]}

Sáez-Torres, I ^{[1
]}

Brieva, L ^{[1
]}

Barberà, N ^{[1
]}

Martínez-Cáceres, EM ^{[1
]}

机构：

[1] Univ Vall Hebron, Hosp Gen, Serv Neurol, Unitat Neuroimmunol Clin, Barcelona 08035, Spain

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 111卷 / 1-2期

关键词：

CD4; CD49d; cerebrospinal fluid; cytokines; multiple sclerosis; relapse;

D O I：

10.1016/S0165-5728(00)00357-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the animal model of multiple sclerosis, experimental autoimmune encephalomyelitis, encephalitogenic T cells differ from the non-encephalitogenic ones in their expression of CD49d. The disease-inducing CD49d(high) and not the CD49d(low) cells enter the brain parenchyma. In this context, we characterized CD4(+)(CD45RO(+))CD49d(high) cells in relapsing-remitting multiple sclerosis (RR-MS) patients. These cells, showing characteristics of activated cells able to produce pro-inflammatory cytokines, were found to be increased in peripheral blood during relapses and present in high numbers in cerebrospinal fluid. These results suggest that the CD4(+)CD45RO(+)CD49d(high) subpopulation in RR-MS patients includes autoreactive cells and may be target for immunotherapy. (C) 2000 Elsevier Science BN. All rights reserved.

引用

页码：215 / 223

页数：9

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