TLR4+896A>G (Asp299Gly) polymorphism is not associated with asthma: a update meta-analysis

被引：0
|
作者：
Yao, Yingshui [1 ,2 ]
Ren, Xiaohua [2 ]
He, Lianping [2 ]
Li, Jie [2 ]
Jin, Yuelong [2 ]
Chang, Weiwei [2 ]
Li, Chaopin [1 ,3 ]
机构：
[1] Anhui Univ Sci & Technol, Sch Earth & Environm, Lab Environm & Hlth, Huainan 232001, Anhui, Peoples R China
[2] Wannan Med Coll, Sch Publ Hlth, Wuhu 241002, Peoples R China
[3] Wannan Med Coll, Dept Med Parasitol, Wuhu 241002, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2014年 / 7卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Toll-Like Receptor 4; single nucleotide polymorphism; asthma; polymorphism; meta-analysis; TOLL-LIKE RECEPTORS; TLR4; CD14; SUSCEPTIBILITY; EXPRESSION; GENES; INFLAMMATION; ATOPY;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Some research reported that polymorphisms in the toll-Like receptor 4 may have influence on asthma risk. Here, we sought to estimate the effects of Toll-Like Receptor 4 (Asp299Gly) genes on asthma risk. Databases including PubMed and Chinese National Knowledge Infrastructure (CNKI) databases were searched to find relevant studies. The odds ratio (OR) with corresponding 95% confidence intervals (CIs) was performed. A total of 12 case-control studies were finally identified. This meta-analysis indicated that no significant association was found between TLR4 (Asp299Gly) genes and asthma risk (OR = 0.91, 95% CI = 0.71-1.12). In conclusion, our findings suggest that TLR4 +896A>G (Asp299Gly) polymorphism may not contribute to the risk of asthma.
引用
收藏
页码：5358 / 5361
页数：4
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