TLR4+896A>G (Asp299Gly) polymorphism is not associated with asthma: a update meta-analysis

被引：0
作者：
Yao, Yingshui [1 ,2 ]
Ren, Xiaohua [2 ]
He, Lianping [2 ]
Li, Jie [2 ]
Jin, Yuelong [2 ]
Chang, Weiwei [2 ]
Li, Chaopin [1 ,3 ]
机构：
[1] Anhui Univ Sci & Technol, Sch Earth & Environm, Lab Environm & Hlth, Huainan 232001, Anhui, Peoples R China
[2] Wannan Med Coll, Sch Publ Hlth, Wuhu 241002, Peoples R China
[3] Wannan Med Coll, Dept Med Parasitol, Wuhu 241002, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2014年 / 7卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Toll-Like Receptor 4; single nucleotide polymorphism; asthma; polymorphism; meta-analysis; TOLL-LIKE RECEPTORS; TLR4; CD14; SUSCEPTIBILITY; EXPRESSION; GENES; INFLAMMATION; ATOPY;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Some research reported that polymorphisms in the toll-Like receptor 4 may have influence on asthma risk. Here, we sought to estimate the effects of Toll-Like Receptor 4 (Asp299Gly) genes on asthma risk. Databases including PubMed and Chinese National Knowledge Infrastructure (CNKI) databases were searched to find relevant studies. The odds ratio (OR) with corresponding 95% confidence intervals (CIs) was performed. A total of 12 case-control studies were finally identified. This meta-analysis indicated that no significant association was found between TLR4 (Asp299Gly) genes and asthma risk (OR = 0.91, 95% CI = 0.71-1.12). In conclusion, our findings suggest that TLR4 +896A>G (Asp299Gly) polymorphism may not contribute to the risk of asthma.
引用
收藏
页码：5358 / 5361
页数：4
相关论文
共 25 条
[1]   Toll-like receptors in the induction of the innate immune response [J].
Aderem, A ;
Ulevitch, RJ .
NATURE, 2000, 406 (6797) :782-787
[2]   Epistatic effect of TLR4 and IL4 genes on the risk of asthma in females [J].
Ådjers, K ;
Karjalainen, J ;
Pessi, T ;
Eklund, C ;
Hurme, M .
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2005, 138 (03) :251-256
[3]  
[Anonymous], CHIN J MICROBIOL IMM
[4]  
[Anonymous], ADV CLIN EXP MED
[5]   Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis [J].
Carvalho, A. ;
Pasqualotto, A. C. ;
Pitzurra, L. ;
Romani, L. ;
Denning, D. W. ;
Rodrigues, F. .
JOURNAL OF INFECTIOUS DISEASES, 2008, 197 (04) :618-621
[6]   Systemic Inflammation Is Associated with Differential Gene Expression and Airway Neutrophilia in Asthma [J].
Fu, Juan-juan ;
Baines, Katherine J. ;
Wood, Lisa G. ;
Gibson, Peter G. .
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 2013, 17 (04) :187-199
[7]   Toll-like receptor 4 (TLR4) expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis [J].
Garay-Malpartida, Humberto M. ;
Mourao, Roberta F. ;
Mantovani, Marluce ;
Santos, Icaro A. ;
Sogayar, Mari C. ;
Goldberg, Anna C. .
BMC IMMUNOLOGY, 2011, 12
[8]   Measuring inconsistency in meta-analyses [J].
Higgins, JPT ;
Thompson, SG ;
Deeks, JJ ;
Altman, DG .
BMJ-BRITISH MEDICAL JOURNAL, 2003, 327 (7414) :557-560
[9]   Quantifying heterogeneity in a meta-analysis [J].
Higgins, JPT ;
Thompson, SG .
STATISTICS IN MEDICINE, 2002, 21 (11) :1539-1558
[10]   Toll-like receptor 2 and Toll-like receptor 4 polymorphisms and susceptibility to asthma and allergic rhinitis: A case-control analysis [J].
Hussein, Yousri M. ;
Awad, Hanan A. ;
Shalaby, Sally M. ;
Ali, Al-Shaymaa A. ;
Alzahrani, Saad S. .
CELLULAR IMMUNOLOGY, 2012, 274 (1-2) :34-38
123