The Amyloid-Tau-Neuroinflammation Axis in the Context of Cerebral Amyloid Angiopathy

被引:33
作者
Cisternas, Pablo [1 ,2 ]
Taylor, Xavier [1 ,2 ]
Lasagna-Reeves, Cristian A. [1 ,2 ]
机构
[1] Indiana Univ Sch Med, Stark Neurosci Res Inst, Indianapolis, IN 46202 USA
[2] Indiana Univ Sch Med, Dept Anat Cell Biol & Physiol, Indianapolis, IN 46202 USA
关键词
cerebral amyloid angiopathy; tau; neuroinflammation; amyloid; GENOME-WIDE ASSOCIATION; CENTRAL-NERVOUS-SYSTEM; TRANSTHYRETIN GENE MUTATION; INTERSTITIAL FLUID DRAINAGE; ALZHEIMERS-DISEASE; MOUSE MODEL; A-BETA; OCULOLEPTOMENINGEAL AMYLOIDOSIS; LEPTOMENINGEAL AMYLOIDOSIS; PRECURSOR PROTEIN;
D O I
10.3390/ijms20246319
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cerebral amyloid angiopathy (CAA) is typified by the cerebrovascular deposition of amyloid. Currently, there is no clear understanding of the mechanisms underlying the contribution of CAA to neurodegeneration. Despite the fact that CAA is highly associated with the accumulation of A beta, other types of amyloids have been shown to associate with the vasculature. Interestingly, in many cases, vascular amyloidosis has been associated with an active immune response and perivascular deposition of hyperphosphorylated tau. Despite the fact that in Alzheimer's disease (AD) a major focus of research has been the understanding of the connection between parenchymal amyloid plaques, tau aggregates in the form of neurofibrillary tangles (NFTs), and immune activation, the contribution of tau and neuroinflammation to neurodegeneration associated with CAA remains understudied. In this review, we discussed the existing evidence regarding the amyloid diversity in CAA and its relation to tau pathology and immune response, as well as the possible contribution of molecular and cellular mechanisms, previously associated with parenchymal amyloid in AD and AD-related dementias, to the pathogenesis of CAA. The detailed understanding of the "amyloid-tau-neuroinflammation" axis in the context of CAA could open the opportunity to develop therapeutic interventions for dementias associated with CAA that are currently being proposed for AD and AD-related dementias.
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页数:19
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