Repeated apomorphine administration alters dopamine D1 and D2 receptor densities in pigeon basal telencephalon

被引:7
作者
Acerbo, MJ
Vyboh, P
Kost'ál, L
Kubíková, L
Delius, JD
机构
[1] Univ Konstanz, D-78457 Constance, Germany
[2] Slovak Acad Sci, Inst Anim Biochem & Genet, Ivanka Pri Dunaji 90028, Slovakia
关键词
apomorphine; sensitization; dopamine receptors; binding assay; pigeons;
D O I
10.1007/s00221-004-2158-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
When pigeons are repeatedly administered a dose of apomorphine they show an increasing behavioral response, much as rodents do. In birds this expresses itself in an augmented pecking response. This sensitization is assumed to be largely due to a conditioning process. Here we present evidence that sensitization is accompanied by an alteration of the D-1 to D-2 dopamine receptor densities. An experimental group of pigeons was repeatedly injected with apomorphine, and a control group with saline. The basal forebrain tissue, known to be rich in dopamine receptors, was subjected to binding assays using tritiated specific D-1 and D-2 dopamine receptor antagonists. There was a trend towards an increase in D-1 and a significant decrease in D-2 receptor densities in apomorphine-treated birds compared to the saline-treated controls. We conclude that extended apomorphine treatment modifies the D-1 dopamine receptor density in the opposite manner to the D-2 dopamine receptor density.
引用
收藏
页码:533 / 537
页数:5
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