Association between body size and colorectal adenoma recurrence

被引:76
作者
Jacobs, Elizabeth T.
Martinez, Maria Elena
Alberts, David S.
Jiang, Ruiyun
Lance, Peter
Lowe, Kimberly A.
Thompson, Patricia A.
机构
[1] Univ Arizona, Arizona Canc Ctr, Mel & Zuckerman Arizona Coll Publ Hlth, Tucson, AZ 85724 USA
[2] Univ Arizona, Arizona Canc Ctr, Tucson, AZ USA
[3] Univ Arizona, Coll Med, Tucson, AZ USA
[4] Univ Arizona, Dept Pathol, Tucson, AZ USA
[5] Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA
关键词
D O I
10.1016/j.cgh.2007.03.022
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background & Aims: Obesity has been associated with increased risk for colorectal adenoma, although its role as a risk factor after polypectomy for recurrence is unclear. Therefore, we sought to evaluate the effect of anthropometric measures of obesity on adenoma after polypectomy. Methods: Subjects with baseline adenomas (n = 2465) and follow-up colonoscopy data were drawn from 2 randomized trials designed to prevent adenoma recurrence. Results: Over a mean follow-up period of 3.1 years presence of a body mass index (BMI) >= 30 kg/m(2) was associated with a nonsignificant 17% increase in the odds for any adenoma recurrence among all subjects (odds ratio [OR], 1.17; 95% confidence interval [CI], 0.92-1.48). This result was confined to men (OR, 1.36; 95% CI, 1.01-1.83) and not observed for women (OR, 0.90; 95% CI, 0.60-1.33). Results for waist circumference did not reach statistical significance, although trends were similar to those for BMI. Analyses of the effects of obesity on more clinically significant lesions demonstrated that high BMI was a slightly stronger risk factor for advanced adenoma recurrences in men (OR, 1.62; 95% CI, 1.04-2.53) when compared with non-advanced lesions (OR, 1.26; 95% CI, 0.91-1.75). In addition, we observed an association for obesity and odds of adenoma recurrence among participants reporting a family history of colorectal cancer (OR, 2.25; 95% CI, 1.32-3.84) but not for those without (OR, 1.00; 95% CI, 0.77 to 1.31; P-int = P = .008). Conclusions: Our results support obesity as a risk factor for subsequent short-interval (mean follow-up time 3.1 years) development of colorectal adenomas, particularly among men and persons with a family history of colorectal cancer. Furthermore, obesity in men appears to be strongly associated with the development of clinically advanced lesions.
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页码:982 / 990
页数:9
相关论文
共 59 条
  • [1] Phase III trial of ursodeoxycholic acid to prevent colorectal adenoma recurrence
    Alberts, DS
    Martínez, ME
    Hess, LM
    Einspahr, JG
    Green, SB
    Bhattacharyya, AK
    Guillen, J
    Krutzsch, M
    Batta, AK
    Salen, G
    Fales, L
    Koonce, K
    Parish, D
    Clouser, M
    Roe, D
    Lance, P
    [J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (11) : 846 - 853
  • [2] Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas
    Alberts, DS
    Martínez, ME
    Roe, DJ
    Guillén-Rodríguez, JM
    Marshall, JR
    van Leeuwen, JB
    Reid, ME
    Ritenbaugh, C
    Vargas, PA
    Bhattacharyya, AB
    Earnest, DL
    Sampliner, RE
    Parish, D
    Koonce, K
    Fales, L
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (16) : 1156 - 1162
  • [3] Does high body fatness increase the risk of presence and growth of colorectal adenomas followed up in situ for 3 years?
    Almendingen, K
    Hofstad, B
    Vatn, MH
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2001, 96 (07) : 2238 - 2246
  • [4] INCREASED RISK OF HIGH-RISK COLORECTAL ADENOMAS IN OVERWEIGHT MEN
    BAYERDORFFER, E
    MANNES, GA
    OCHSENKUHN, T
    KOPCKE, W
    WIEBECKE, B
    PAUMGARTNER, G
    [J]. GASTROENTEROLOGY, 1993, 104 (01) : 137 - 144
  • [5] Bird CL, 1998, AM J EPIDEMIOL, V147, P670, DOI 10.1093/oxfordjournals.aje.a009508
  • [6] Colorectal adenoma characteristics as predictors of recurrence
    Bonithon-Kopp, C
    Piard, F
    Fenger, C
    Cabeza, E
    O'Morain, C
    Kronborg, O
    Faivre, J
    [J]. DISEASES OF THE COLON & RECTUM, 2004, 47 (03) : 323 - 333
  • [7] SUGAR, MEAT, AND FAT INTAKE, AND NONDIETARY RISK-FACTORS FOR COLON-CANCER INCIDENCE IN IOWA WOMEN (UNITED-STATES)
    BOSTICK, RM
    POTTER, JD
    KUSHI, LH
    SELLERS, TA
    STEINMETZ, KA
    MCKENZIE, DR
    GAPSTUR, SM
    FOLSOM, AR
    [J]. CANCER CAUSES & CONTROL, 1994, 5 (01) : 38 - 52
  • [8] Value of body fat mass vs anthropometric obesity indices in the assessment of metabolic risk factors
    Bosy-Westphal, A
    Geisler, C
    Onur, S
    Korth, O
    Selberg, O
    Schrezenmeir, J
    Müller, MJ
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 2006, 30 (03) : 475 - 483
  • [9] Energy intake, body mass index, physical activity, and the colorectal adenoma-carcinoma sequence
    Boutron-Ruault, MC
    Senesse, P
    Méance, S
    Belghiti, C
    Faivre, J
    [J]. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2001, 39 (01): : 50 - 57
  • [10] DIFFERENTIAL-EFFECTS OF ORAL CONJUGATED ESTROGENS AND TRANSDERMAL ESTRADIOL ON INSULIN-LIKE GROWTH-FACTOR-1, GROWTH-HORMONE AND SEX-HORMONE BINDING GLOBULIN SERUM LEVELS
    CAMPAGNOLI, C
    BIGLIA, N
    ALTARE, F
    LANZA, MG
    LESCA, L
    CANTAMESSA, C
    PERIS, C
    FIORUCCI, GC
    SISMONDI, P
    [J]. GYNECOLOGICAL ENDOCRINOLOGY, 1993, 7 (04) : 251 - 258