A formal synthesis of (-)-swainsonine from a chiral aziridine

被引：28

作者：

Choi, Hwan Geun ^{[1
]}

Kwon, Ji Hye ^{[1
]}

Kim, Jong Chan ^{[1
]}

Lee, Won Koo ^{[1
]}

Eum, Heesung ^{[2
]}

Ha, Hyun-Joon ^{[2
]}

机构：

[1] Sogang Univ, Dept Chem, Seoul 121742, South Korea

[2] Hankuk Univ Foreign Studies, Dept Chem, Yongin 449719, Kyunggi Do, South Korea

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 25期

基金：

新加坡国家研究基金会;

关键词：

ASYMMETRIC-SYNTHESIS; EFFICIENT SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; DECARBONYLATION; SWAINSONINE; INHIBITORS; ALCOHOLS; ANALOGS;

D O I：

10.1016/j.tetlet.2010.04.069

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A formal synthesis of enantiomerically pure (-)-swainsonine was successfully achieved using intramolecular cyclization of the amino alcohol 4 which was derived from a readily available 1-(R)-alpha-methylbenzylaziridine-2-carboxylic acid (-)-menthol ester 6. (C) 2010 Elsevier Ltd. All rights reserved.

引用

收藏

页码：3284 / 3285

页数：2

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