Descriptive Phenotype of Obsessive Compulsive Symptoms in Males With Duchenne Muscular Dystrophy

被引:18
作者
Lee, Angela J. [1 ]
Buckingham, Edward T. [2 ]
Kauer, Aaron J. [2 ]
Mathews, Katherine D. [3 ,4 ]
机构
[1] Univ Iowa, Carver Coll Med, 375 Newton Rd, Iowa City, IA 52246 USA
[2] Univ Iowa Hosp & Clin, Dept Psychiat, Iowa City, IA 52242 USA
[3] Univ Iowa Hosp & Clin, Dept Pediat, Iowa City, IA 52242 USA
[4] Univ Iowa Hosp & Clin, Dept Neurol, Iowa City, IA 52242 USA
关键词
Duchenne muscular dystrophy; internalizing disorders; OCD; anxiety; SSRIs; AUTISM SPECTRUM DISORDER; QUALITY-OF-LIFE; BEHAVIOR PROBLEMS; FOLLOW-UP; ADOLESCENTS; CHILDREN; ANXIETY; ASSOCIATION; DISEASE; HEALTH;
D O I
10.1177/0883073818774439
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Increased rates of clinically significant internalizing disorders (obsessive compulsive disorder, anxiety, and depression) have been demonstrated in males with Duchenne muscular dystrophy, and a Duchenne muscular dystrophy neuropsychiatric syndrome has been suggested. Although symptoms of depression are widely recognized, some of the other internalizing symptoms are less frequently identified. Through a retrospective chart review of 107 males with Duchenne muscular dystrophy, we identified 15 patients with obsessive compulsive disorder spectrum symptoms; 11 of those also had anxiety symptoms. Many of these patients received selective serotonin reuptake inhibitor treatment, commonly noting improvement in symptoms. Here we describe the clinical features of several patients in detail to facilitate early recognition and consideration for treatment for patients with Duchenne muscular dystrophy and internalizing psychiatric symptoms. The results of this cohort showed a significantly increased rate of obsessive compulsive disorder spectrum symptoms (14%) compared to the general population.
引用
收藏
页码:572 / 579
页数:8
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