Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds

被引：31

作者：

Kato, Eisuke ^{[1
]}

Kawabata, Jun ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Agr, Div Appl Biosci, Lab Food Biochem,Kita Ku, Sapporo, Hokkaido 0608589, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 15期

关键词：

Puerarin; Isoflavone; Diabetes mellitus; PPAR gamma; Glucose uptake; RAT SOLEUS MUSCLE; KAEMPFEROL; CELLS;

D O I：

10.1016/j.bmcl.2010.06.077

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical treatment of diabetes mellitus is widely studied and controlling of blood glucose level is the main course of therapy. In type 2 diabetes mellitus, insulin resistance is the major problem. An isoflavone C-glucoside, puerarin (1), is known to enhance glucose uptake into the insulin sensitive cell and is thought to be a candidate for treatment of diabetes mellitus. We synthesized 1 and several derivatives to apply for the structure-activity relationship study. The result against 3T3-L1 adipocyte indicated that the C-glucoside part of 1 is unconcerned in its activity when tested in vitro and the main structure responsible for its activity was the isoflavone moiety. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4333 / 4336

页数：4

共 14 条

[1] Anti-inflammatory effects of isoflavones are dependent on flow and human endothelial cell PPARγ [J].