Ancient European dog genomes reveal continuity since the Early Neolithic

被引：154

作者：

Botigue, Laura R. ^{[1
]}

Song, Shiya ^{[2
]}

Scheu, Amelie ^{[3
,4
]}

Gopalan, Shyamalika ^{[1
]}

Pendleton, Amanda L. ^{[5
]}

Oetjens, Matthew ^{[5
]}

Taravella, Angela M. ^{[5
]}

Seregely, Timo ^{[6
]}

Zeeb-Lanz, Andrea ^{[7
]}

Arbogast, Rose-Marie ^{[8
]}

Bobo, Dean ^{[1
]}

Daly, Kevin ^{[4
]}

Nder, Martina Unterla ^{[3
]}

Burger, Joachim ^{[3
]}

Kidd, Jeffrey M. ^{[2
,5
]}

Veeramah, Krishna R. ^{[1
]}

机构：

[1] SUNY Stony Brook, Dept Ecol & Evolut, Stony Brook, NY 11794 USA

[2] Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA

[3] Johannes Gutenberg Univ Mainz, Palaeogenet Grp, D-55099 Mainz, Germany

[4] Trinity Coll Dublin, Smurfit Inst Genet, Dublin 2, Ireland

[5] Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA

[6] Univ Bamberg, Inst Archaeol Heritage Sci & Art Hist, Dept Prehist Archaeol, D-96045 Bamberg, Germany

[7] Aussenstelle Speyer, Direkt Landesarchaol, Gen Direkt Kulturelles Erbe Rheinland Pfalz, D-67346 Speyer, Germany

[8] CNRS UMR 7044 UDS, 5 Allee Gen Rouvillois, F-67083 Strasbourg, France

来源：

NATURE COMMUNICATIONS | 2017年 / 8卷

关键词：

GENETIC-STRUCTURE; COPY NUMBER; ADMIXTURE; DOMESTICATION; HISTORY; ORIGIN; PATTERNS; INFERENCE; DAMAGE;

D O I：

10.1038/ncomms16082

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Europe has played a major role in dog evolution, harbouring the oldest uncontested Palaeolithic remains and having been the centre of modern dog breed creation. Here we sequence the genomes of an Early and End Neolithic dog from Germany, including a sample associated with an early European farming community. Both dogs demonstrate continuity with each other and predominantly share ancestry with modern European dogs, contradicting a previously suggested Late Neolithic population replacement. We find no genetic evidence to support the recent hypothesis proposing dual origins of dog domestication. By calibrating the mutation rate using our oldest dog, we narrow the timing of dog domestication to 20,000-40,000 years ago. Interestingly, we do not observe the extreme copy number expansion of the AMY2B gene characteristic of modern dogs that has previously been proposed as an adaptation to a starch-rich diet driven by the widespread adoption of agriculture in the Neolithic.

引用

页数：11

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