Molecular motors

被引：905
作者：
Schliwa, M [1 ]
Woehlke, G [1 ]
机构：
[1] Univ Munich, Adolf Butenandt Inst, D-80336 Munich, Germany
来源：
NATURE | 2003年 / 422卷 / 6933期
关键词：
D O I：
10.1038/nature01601
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Life implies movement. Most forms of movement in the living world are powered by tiny protein machines known as molecular motors. Among the best known are motors that use sophisticated intramolecular amplification mechanisms to take nanometre steps along protein tracks in the cytoplasm. These motors transport a wide variety of cargo, power cell locomotion, drive cell division and, when combined in large ensembles, allow organisms to move. Motor defects can lead to severe diseases or may even be lethal. Basic principles of motor design and mechanism have now been derived, and an understanding of their complex cellular roles is emerging.
引用
收藏
页码：759 / 765
页数：7
相关论文
共 101 条
  • [1] Phosphorylation by cdc2-cyclinB1 kinase releases cytoplasmic dynein from membranes
    Addinall, SG
    Mayr, PS
    Doyle, S
    Sheehan, JK
    Woodman, PG
    Allan, VJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (19) : 15939 - 15944
  • [2] [Anonymous], 2001, MECH MOTOR PROTEINS
  • [3] Evidence that an interaction between EB1 and p150Glued is required for the formation and maintenance of a radial microtubule array anchored at the centrosome
    Askham, JM
    Vaughan, KT
    Goodson, HV
    Morrison, EE
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (10) : 3627 - 3645
  • [4] Avraham K.B., 2002, Ernst Schering Res. Found. Workshop, V36, P271
  • [5] Kinesin-dependent axonal transport is mediated by the Sunday driver (SYD) protein
    Bowman, AB
    Kamal, A
    Ritchings, BW
    Philp, AV
    McGrail, M
    Gindhart, JG
    Goldstein, LSB
    [J]. CELL, 2000, 103 (04) : 583 - 594
  • [6] A function for kinesin I in the posterior transport of oskar mRNA and Staufen protein
    Brendza, RP
    Serbus, LR
    Duffy, JB
    Saxton, WM
    [J]. SCIENCE, 2000, 289 (5487) : 2120 - 2122
  • [7] Myosin va movements in normal and dilute-lethal axons provide support for a dual filament motor complex
    Bridgman, PC
    [J]. JOURNAL OF CELL BIOLOGY, 1999, 146 (05) : 1045 - 1060
  • [8] Cooperation between microtubule- and actin-based motor proteins
    Brown, SS
    [J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1999, 15 : 63 - 80
  • [9] Dynein structure and power stroke
    Burgess, SA
    Walker, ML
    Sakakibara, H
    Knight, PJ
    Oiwa, K
    [J]. NATURE, 2003, 421 (6924) : 715 - 718
  • [10] In vivo analysis of Drosophila bicoid mRNA localization reveals a novel microtubule-dependent axis specification pathway
    Cha, BJ
    Koppetsch, BS
    Theurkauf, WE
    [J]. CELL, 2001, 106 (01) : 35 - 46
12345678910