A new attenuated Mycobacterium bovis vaccine protects brushtail possums (Trichosurus vulpecula) against experimental tuberculosis infection

被引：17
作者：
Collins, Desmond M. [1 ]
de Lisle, Geoffrey W.
Aldwell, Frank E.
Buddle, Bryce A.
机构：
[1] AgRes, Wallaceville Anim Res Ctr, Upper Hutt, New Zealand
[2] Univ Otago, Ctr Innovat, Dunedin, New Zealand
来源：
VACCINE | 2007年 / 25卷 / 24期
关键词：
vaccine; tuberculosis; possums;
D O I：
10.1016/j.vaccine.2007.04.014
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Vaccination of wildlife against bovine tuberculosis is being actively considered in countries that have wildlife reservoirs of Mycobacterium bovis infection. A newly attenuated strain of M. bovis (WAg533) was produced as part of a programme to develop a better vaccine than BCG to control tuberculosis in brushtail possums in New Zealand. The vaccine efficacy of WAg533 in possums was compared to BCG using three different methods of inoculation (conjunctivallintranasal, oral and sub-cutaneous) followed by aerosol challenge. Overall, WAg533 was a more potent vaccine than BCG and by two methods of inoculation gave more measures of protection that were significantly different from controls. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4659 / 4664
页数：6
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