Multi-haem cytochromes in Shewanella oneidensis MR-1: structures, functions and opportunities

被引:195
作者
Breuer, Marian [1 ]
Rosso, Kevin M. [2 ]
Blumberger, Jochen [1 ]
Butt, Julea N. [3 ,4 ]
机构
[1] UCL, Dept Phys & Astron, London WC1E 6BT, England
[2] Pacific NW Natl Lab, Richland, WA 99352 USA
[3] Univ E Anglia, Sch Biol Sci, Norwich NR4 7TJ, Norfolk, England
[4] Univ E Anglia, Sch Chem, Norwich NR4 7TJ, Norfolk, England
基金
英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;
关键词
respiration; cytochrome; haem; electron transfer; Marcus theory; redox potential; C-TYPE CYTOCHROME; OUTER-MEMBRANE CYTOCHROMES; EXTRACELLULAR ELECTRON-TRANSPORT; PHOTOSYNTHETIC REACTION-CENTER; REORGANIZATION FREE-ENERGIES; SMALL TETRAHEME CYTOCHROME; SELF-EXCHANGE REACTION; RAY CRYSTAL-STRUCTURE; IRON-SULFUR CLUSTERS; ANAEROBIC RESPIRATION;
D O I
10.1098/rsif.2014.1117
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Multi-haem cytochromes are employed by a range of microorganisms to transport electrons over distances of up to tens of nanometres. Perhaps the most spectacular utilization of these proteins is in the reduction of extracellular solid substrates, including electrodes and insoluble mineral oxides of Fe(III) and Mn(III/IV), by species of Shewanella and Geobacter. However, multi-haem cytochromes are found in numerous and phylogenetically diverse prokaryotes where they participate in electron transfer and redox catalysis that contributes to biogeochemical cycling of N, S and Fe on the global scale. These properties of multi-haem cytochromes have attracted much interest and contributed to advances in bioenergy applications and bioremediation of contaminated soils. Looking forward, there are opportunities to engage multi-haem cytochromes for biological photovoltaic cells, microbial electrosynthesis and developing bespoke molecular devices. As a consequence, it is timely to review our present understanding of these proteins and we do this here with a focus on the multitude of functionally diverse multi-haem cytochromes in Shewanella oneidensis MR-1. We draw on findings from experimental and computational approaches which ideally complement each other in the study of these systems: computational methods can interpret experimentally determined properties in terms of molecular structure to cast light on the relation between structure and function. We show how this synergy has contributed to our understanding of multi-haem cytochromes and can be expected to continue to do so for greater insight into natural processes and their informed exploitation in biotechnologies.
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页数:27
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