Polyketides from the Mangrove-derived fungal endophyte Pestalotiopsis clavispora

被引：36
作者：
Hemphill, Catalina Francis Perez [1 ]
Daletos, Georgios [1 ]
Liu, Zhen [1 ]
Lin, Wenhan [2 ]
Proksch, Peter [1 ]
机构：
[1] Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, Univ Str 1,Geb 26-23, D-40225 Dusseldorf, Germany
[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 19期
关键词：
Pestalotiopsis clavispora; Pestalpolyol; Cytotoxic activity; Polyketide biosynthesis; BIOSYNTHESIS; METABOLITES; AGENTS; ACID;
D O I：
10.1016/j.tetlet.2016.03.101
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Six new polyketide derivatives, including pestalpolyol I (1), pestapyrones A (2) and B (3), (R)-periplanetin D (6), pestaxanthone (7), norpestaphthalide A (8), and an isolation artifact pestapyrone C (4), were obtained from extracts of the endophytic fungus Pestalotiopsis clavispora isolated from the Mangrove plant Rhizophora harrisonii. In addition, seven known metabolites, including similanpyrone B (5), (R,S)-5,7-dihydroxy-3-(1-hydroxyethyl)phthalide (9), for which we propose the trivial name norpestaphthalide B, pestaphthalides A (10) and B (11), 2-epi-herbarumin II (12), and pestalotiollides A (13) and B (14) were isolated. The structures of the new compounds were unambiguously elucidated on the basis of one- and two-dimensional NMR spectroscopy, as well as by high -resolution mass spectrometry. All compounds were tested for their cytotoxicity against the mouse lymphoma cell line L5178Y. Compound 1 exhibited strong activity with an IC50 value of 4.10 mu M. All other compounds (2-14) proved to be inactive (IC50 > mu M) in this assay. (C) 2016 Elsevier Ltd. All rights reserved.
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页码：2078 / 2083
页数：6
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