Resolution of inflammation: state of the art, definitions and terms

被引:866
作者
Serhan, Charles N.
Brain, Sue D.
Buckley, Christopher D.
Gilroy, Derek W.
Haslett, Christopher
O'Neill, Luke A. J.
Perretti, Mauro
Rossi, Adriano G.
Wallace, John L.
机构
[1] Brigham & Womens Hosp, Ctr Expt Therapeut & Reperfus Injury, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Oral Med Infect & Immun, Harvard Sch Dent Med, Boston, MA 02115 USA
[3] Kings Coll London, Div Cardiovasc, London WC2R 2LS, England
[4] UCL, Ctr Clin Pharmacol & Therapeut, Div Med, London, England
[5] Univ Edinburgh, MRC Ctr Inflammat Res, Queens Med Res Inst, Edinburgh, Midlothian, Scotland
[6] Trinity Coll Dublin, Sch Biochem & Immunol, Dublin, Ireland
[7] Queen Mary Univ London, William Harvey Res Inst, London, England
[8] Univ Calgary, Inflammat Res Network, Calgary, AB, Canada
基金
英国医学研究理事会;
关键词
anti-inflammatories; leukocytes; lipid mediators; chemokines; cytokines;
D O I
10.1096/fj.06-7227rev
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A recent focus meeting on Controlling Acute Inflammation was held in London, April 27-28, 2006, organized by D.W. Gilroy and S.D. Brain for the British Pharmacology Society. We concluded at the meeting that a consensus report was needed that addresses the rapid progress in this emerging field and details how the specific study of resolution of acute inflammation provides leads for novel anti-inflammatory therapeutics, as well as defines the terms and key components of interest in the resolution process within tissues as appreciated today. The inflammatory response protects the body against infection and injury but can itself become dysregulated with deleterious consequences to the host. It is now evident that endogenous biochemical pathways activated during defense reactions can counter-regulate inflammation and promote resolution. Hence, resolution is an active rather than a passive process, as once believed, which now promises novel approaches for the treatment of inflammation-associated diseases based on endogenous agonists of resolution.
引用
收藏
页码:325 / 332
页数:8
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