Marfan syndrome and mitral valve prolapse

被引：32

作者：

Weyman, AE ^{[1
]}

Scherrer-Crosbie, M ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Dept Med, Cardiac Ultrasound Lab, Cardiol Div, Boston, MA 02114 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 114卷 / 11期

关键词：

D O I：

10.1172/JCI200423701

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Mitral valve prolapse (MVP), an abnormal displacement into the left atrium of a thickened and redundant mitral valve during systole, is a relatively frequent abnormality in humans and may be associated with serious complications. A recent study implicates fibrillin-1, a component of extracellular matrix microfibrils, in the pathogenesis of a murine model of MVP (see the related article beginning on page 1586). This investigation represents an initial step toward understanding the mechanisms involved in human MVP disease and the development of potential treatments.

引用

页码：1543 / 1546

页数：4

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